{"id":6132,"date":"2025-09-15T20:11:51","date_gmt":"2025-09-15T20:11:51","guid":{"rendered":"https:\/\/polikistikover.net\/yeni\/?page_id=6132"},"modified":"2025-11-16T05:21:52","modified_gmt":"2025-11-16T05:21:52","slug":"polikistik-over-sendromunda-insulin-direnci-ve-seker-hastaligi","status":"publish","type":"page","link":"https:\/\/polikistikover.net\/yeni\/polikistik-over-sendromunda-insulin-direnci-ve-seker-hastaligi\/","title":{"rendered":"Polikistik Over Sendromu\u2019nda \u0130ns\u00fclin Direnci ve \u015eeker Hastal\u0131\u011f\u0131"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<p class=\"has-text-align-center wp-embed-aspect-16-9 wp-has-aspect-ratio\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-dark-pink-color\">Polikistik over sendromu\u2019nda fazla kilolu ve \u015fi\u015fman olan veya normal kilolu fakat bel \u00e7evresi kal\u0131n&nbsp;(erkek tipi ya\u011flanma) olan kad\u0131nlar\u0131n b\u00fcy\u00fck \u00e7o\u011funlu\u011funda&nbsp;ins\u00fclin direnci&nbsp; g\u00f6r\u00fclmektedir(1,2,9,10).<\/mark><\/strong><\/p>\n\n\n\n<p class=\"wp-embed-aspect-16-9 wp-has-aspect-ratio\"> Polikistik over sendromu olan normal kilolu veya zay\u0131f ya da fazla kilolu veya&nbsp;\u015fi\u015fman kad\u0131nlar\u0131n bir k\u0131sm\u0131nda kar\u0131n ve bel \u00e7evresinde&nbsp;ya\u011f miktar\u0131 fazla <a href=\"http:\/\/polikistikover.net\/polikistik-over-sendromunda-vucut-kas-ve-yag-miktarlari-ve-dagilimlari\/\"><\/a>(erkek tipi ya\u011flanma)&nbsp;oldu\u011fu i\u00e7in ins\u00fclin direncinin bir g\u00f6stergesi olan bel \u00e7evresi&nbsp;kal\u0131nl\u0131\u011f\u0131 g\u00f6r\u00fclmektedir(27,28,29,30).<\/p>\n\n\n\n<p class=\"has-text-align-center wp-embed-aspect-16-9 wp-has-aspect-ratio\"> <strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-dark-pink-color\">\u0130ns\u00fclin direncinin ilerlemesi, k\u00f6t\u00fcye gitmesi sonucunda&nbsp;bozulmu\u015f glukoz (\u015feker) tolerans\u0131 ve \u015feker hastal\u0131\u011f\u0131 (Diabetes mellitus)&nbsp;geli\u015fmektedir(3,4,5,6,7,8,11).<\/mark><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"#zay\u0131fpolikistikover #normalkilolupolikistikover #ins\u00fclindirenci #darkal\u00e7al\u0131kad\u0131nlar #belya\u011flanmas\u0131\" width=\"1320\" height=\"743\" src=\"https:\/\/www.youtube.com\/embed\/q4HCKKFIcH4?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"has-text-align-center\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-dark-pink-color\">Polikistik over sendromu olan kad\u0131nlarda genellikle ins\u00fclin direnci daha h\u0131zl\u0131 bir \u015fekilde ilerledi\u011fi, k\u00f6t\u00fcye gitti\u011fi i\u00e7in bozulmu\u015f \u015feker&nbsp;tolerans\u0131 ve \u015feker hastal\u0131\u011f\u0131 ergenlik (adolesan) d\u00f6neminden itibaren \u00e7ok daha gen\u00e7 ya\u015flarda ortaya \u00e7\u0131kmaktad\u0131r(6,7,12).<\/mark><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"#polikistikover #belya\u011flanmas\u0131 #karaci\u011ferya\u011flanmas\u0131 #kal\u00e7aya\u011flanmas\u0131 #ins\u00fclindirenci #ya\u011fh\u00fccresi\" width=\"1320\" height=\"743\" src=\"https:\/\/www.youtube.com\/embed\/a7IoMfFaPrs?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"has-text-align-center\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-dark-pink-color\">Son y\u0131llarda do\u011fal olmayan ve haz\u0131rlanmas\u0131 kolay besinlere y\u00f6nelen kad\u0131nlar&nbsp;eskiden protein a\u011f\u0131rl\u0131kl\u0131 beslenirken \u015fimdi art\u0131k daha \u00e7ok karbonhidrat t\u00fcketmeye ba\u015flad\u0131lar.&nbsp;Hareketsiz bir ya\u015fam s\u00fcren kad\u0131nlarda beslenme bi\u00e7imindeki bu de\u011fi\u015fiklik ins\u00fclin direncinin ortaya \u00e7\u0131kmas\u0131n\u0131 kolayla\u015ft\u0131rmaktad\u0131r.<\/mark><\/strong><\/p>\n\n\n\n<p>\u0130ns\u00fclin direnci olan ki\u015filerde pankreas bu direnci yenmek i\u00e7in fazla miktarda ins\u00fclin \u00fcretir. Bunun sonucunda kan dola\u015f\u0131m\u0131nda bulunan ins\u00fclin miktar\u0131 artar (Hiperins\u00fclinemi).&nbsp;<\/p>\n\n\n\n<p>Polikistik over sendromu\u2019nu olu\u015fturan&nbsp;<a href=\"http:\/\/polikistikover.net\/polikistik-over-sendromunun-cesitleri-alt-gruplari\/\"><\/a>gruplar\u0131n&nbsp;&nbsp;(A,B,C)&nbsp;hepsinde ins\u00fclin direnci g\u00f6r\u00fclebilmektedir.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"576\" src=\"https:\/\/polikistikover.net\/yeni\/wp-content\/uploads\/2025\/09\/image-54.png\" alt=\"\" class=\"wp-image-6577\" srcset=\"https:\/\/polikistikover.net\/yeni\/wp-content\/uploads\/2025\/09\/image-54.png 768w, https:\/\/polikistikover.net\/yeni\/wp-content\/uploads\/2025\/09\/image-54-300x225.png 300w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-center\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-dark-blue-color\">\u0130ns\u00fclin direncine ba\u011fl\u0131 olarak fazla miktarda \u00fcretilen ins\u00fclin hormonunun polikistik over sendromu olan kad\u0131nlarda yapt\u0131\u011f\u0131 etkiler a\u015fa\u011f\u0131da belirtilmi\u015ftir;<\/mark><\/strong><\/p>\n\n\n\n<p><strong><mark style=\"background-color:#dcda2b\" class=\"has-inline-color\">1-<\/mark><\/strong>Kan dola\u015f\u0131m\u0131nda fazla miktarda bulunan \u0130ns\u00fclin hormonu do\u011frudan yumurtal\u0131\u011fa giderek yumurtal\u0131kta erkeklik hormonlar\u0131n\u0131n \u00fcretimini artt\u0131rmaktad\u0131r (hiperandrogenism)(13,14,15,16,17,26,40).<\/p>\n\n\n\n<p><mark style=\"background-color:#e0c529\" class=\"has-inline-color has-dark-color\">2-<\/mark>Kan dola\u015f\u0131m\u0131nda fazla miktarda bulunan ins\u00fclin hormonu beyinde yer alan&nbsp;hipofiz bezinde erkeklik hormonlar\u0131n\u0131n yumurtal\u0131kta yap\u0131lmas\u0131n\u0131 sa\u011flayan&nbsp;LH (luteinizing hormon) \u00fcretimini&nbsp;artt\u0131rmaktad\u0131r(18,19,20).&nbsp;LH (luteinizing hormon) miktar\u0131n\u0131n artmas\u0131 erkeklik hormonlar\u0131n\u0131n&nbsp;yap\u0131m\u0131n\u0131 artt\u0131rmaktad\u0131r (hiperandrogenism)(18,21,26,40).<\/p>\n\n\n\n<p><mark style=\"background-color:#dfc322\" class=\"has-inline-color\">3-<\/mark>Karaci\u011ferde \u00fcretilen Sex Hormone Binding Globulin&nbsp;(SHBG) erkeklik hormonlar\u0131na ba\u011flanarak onlar\u0131n etkinli\u011fini azaltmaktad\u0131r(22,23). Kan dola\u015f\u0131m\u0131nda fazla miktarda bulunan ins\u00fclin hormonu Sex Hormone Binding Globulin&nbsp;(SHBG) \u00fcretimini azaltmaktad\u0131r(24).<\/p>\n\n\n\n<p><mark style=\"background-color:#d1b01d\" class=\"has-inline-color has-dark-color\">4-<\/mark>Kan dola\u015f\u0131m\u0131nda fazla miktarda bulunan ins\u00fclin hormonu hem do\u011frudan yumurtal\u0131\u011fa giderek hem de&nbsp;hipofiz bezinde LH (luteinizing hormon) \u00fcretimini&nbsp;artt\u0131rarak yumurtay\u0131 i\u00e7inde ta\u015f\u0131yan keseci\u011fin (folik\u00fcl) b\u00fcy\u00fcmesini ve yumurtlamay\u0131 engellemektedir(25,39). <\/p>\n\n\n\n<p>\u0130ns\u00fclin direncine ba\u011fl\u0131 olarak fazla miktarda \u00fcretilen ins\u00fclin hormonu polikistik over sendromu olan kad\u0131nlarda erkeklik hormonlar\u0131n\u0131n miktar\u0131n\u0131 ve etkinli\u011fini artt\u0131rd\u0131\u011f\u0131 i\u00e7in&nbsp;t\u00fcylenme art\u0131\u015f\u0131, <a href=\"http:\/\/polikistikover.net\/polikistik-over-sendromunda-sivilce-ve-tedavisi\/\"><\/a>sivilce&nbsp;ve <a href=\"http:\/\/polikistikover.net\/sac-dokulmesi-ve-polikistik-over-sendromu\/\"><\/a>sa\u00e7 d\u00f6k\u00fclmesine, yumurta geli\u015fiminin durmas\u0131na (anovulasyon) ya da yava\u015flamas\u0131na (oligoovulasyon) ba\u011fl\u0131 olarak da adet kanamas\u0131n\u0131n gecikmesi (oligomenorrhea) veya olmamas\u0131 (amenorrhea) \u015feklinde&nbsp;adet d\u00fczensizli\u011fine&nbsp;neden olmaktad\u0131r.<\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong>Tedavi<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-dark-pink-color\">Tedavinin amac\u0131 ins\u00fclin direncine kar\u015f\u0131&nbsp;\u201d\u0130ns\u00fclin duyarl\u0131l\u0131\u011f\u0131\u201d&nbsp;n\u0131n artt\u0131r\u0131lmas\u0131d\u0131r(31,32,33,34). \u0130ns\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131n artmas\u0131 ile birlikte&nbsp;ins\u00fclin direnci azal\u0131r.&nbsp;\u0130ns\u00fclin direncinin azalmas\u0131 sonucunda pankreas daha az ins\u00fclin \u00fcretmeye ba\u015flar. Kan dola\u015f\u0131m\u0131nda bulunan ins\u00fclin miktar\u0131 azal\u0131r ve fazla \u00fcretilen ins\u00fclin hormonunun yapt\u0131\u011f\u0131 etkiler (t\u00fcylenme art\u0131\u015f\u0131,&nbsp;sivilce,&nbsp;sa\u00e7 d\u00f6k\u00fclmesi&nbsp;ve&nbsp;adet d\u00fczensizli\u011fi) azal\u0131r veya ortadan kalkar.&nbsp;<\/mark><\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-dark-pink-color\">\u015eeker hastal\u0131\u011f\u0131n\u0131n&nbsp;(Diabetes Mellitus)&nbsp;ba\u015flang\u0131\u00e7 a\u015famas\u0131 ins\u00fclin direncidir. \u0130ns\u00fclin direncinin k\u00f6t\u00fcye gitmesi, ilerlemesi sonucunda&nbsp;\u015feker (glukoz) intolerans\u0131 geli\u015fir ve en son a\u015famada da \u015feker hastal\u0131\u011f\u0131 ortaya \u00e7\u0131kar.&nbsp;<\/mark><\/strong><\/p>\n\n\n\n<p>Polikistik over sendromu olan kad\u0131nlarda&nbsp;ins\u00fclin direnci \u00e7ok daha gen\u00e7 ya\u015flarda bir sonraki a\u015fama olan \u015feker&nbsp;intolerans\u0131, ve&nbsp;en son a\u015fama olan \u015feker hastal\u0131\u011f\u0131na d\u00f6n\u00fc\u015fmektedir(11,12).<\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-dark-pink-color\">\u0130ns\u00fclin direnci veya&nbsp;\u015feker intolerans\u0131 a\u015famas\u0131ndan \u00f6nce sorun tespit edilirse ins\u00fclin direnci ve&nbsp;\u015feker intolerans\u0131n\u0131n \u015feker hastal\u0131\u011f\u0131na d\u00f6n\u00fc\u015fmesi \u00f6nlenebilir(35). Bu nedenle&nbsp;polikistik over sendromu olan&nbsp;b\u00fct\u00fcn kad\u0131nlarda ya\u015f\u0131na bak\u0131lmaks\u0131z\u0131n ins\u00fclin direnci, \u015feker&nbsp;intolerans\u0131 ve \u015feker hastal\u0131\u011f\u0131 olup olmad\u0131\u011f\u0131 ara\u015ft\u0131r\u0131lmal\u0131d\u0131r(35,36).<\/mark><\/strong><\/p>\n\n\n\n<p>\u0130ns\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131n artt\u0131r\u0131lmas\u0131 i\u00e7in tek ba\u015f\u0131na ila\u00e7 tedavisi yeterli olmamaktad\u0131r(37).<\/p>\n\n\n\n<p> Polikistik Over Sendromu olan kad\u0131nlar\u0131n ya\u015fam tarzlar\u0131n\u0131n da&nbsp;beslenme bi\u00e7imi ve g\u00fcnl\u00fck hareket a\u00e7\u0131s\u0131ndan d\u00fczenlenmesi gerekmektedir(38). <\/p>\n\n\n\n<p>\u0130ns\u00fclin direnci olan kad\u0131nlarda beslenme bi\u00e7imi kanda bulunan ins\u00fclin miktar\u0131n\u0131 d\u00fc\u015f\u00fck seviyede ve sabit tutacak \u015fekilde olmal\u0131d\u0131r. \u0130ns\u00fclin yap\u0131m\u0131n\u0131 karbonhidrat i\u00e7eren besinler, protein i\u00e7eren besinlerden \u00e7ok daha fazla miktarda artt\u0131rmaktad\u0131r. <\/p>\n\n\n\n<p>\u0130nsan v\u00fccudunu kas, ya\u011f, su ve kemik olu\u015fturmaktad\u0131r. Kas ile ya\u011f beslenme bi\u00e7imi ve hareket miktar\u0131na ba\u011fl\u0131 olarak birbirine d\u00f6n\u00fc\u015febilmektedir. Kas (\u0130skelet kas\u0131) miktar\u0131 artt\u0131k\u00e7a ya\u011f miktar\u0131 azalmaktad\u0131r. Kaslar ya\u011flar\u0131 enerji (kalori) olarak kullanarak ya\u011flar\u0131n azalmas\u0131na neden olmaktad\u0131r.&nbsp;<\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-dark-pink-color\">Kas fazla miktarda ise&nbsp;ki\u015finin g\u00fcnl\u00fck hareketi&nbsp;fazla olmasa bile kas miktar\u0131 ile do\u011fru orant\u0131l\u0131 olarak daha fazla&nbsp;miktarda ya\u011f&nbsp;enerji (kalori) olarak t\u00fcketilmektedir. Buna kar\u015f\u0131l\u0131k ya\u011flar kaslardan \u00e7ok daha az miktarda enerji (kalori)&nbsp;harcad\u0131\u011f\u0131 i\u00e7in kas miktar\u0131 az ve ya\u011f miktar\u0131 fazla olan ki\u015filerde metabolizma h\u0131z\u0131n\u0131n yava\u015flamas\u0131na ba\u011fl\u0131 olarak bir k\u0131s\u0131r d\u00f6ng\u00fc olu\u015fmakta ve bunun sonucunda ya\u011flanma&nbsp;zaman i\u00e7inde gittik\u00e7e artmaktad\u0131r.&nbsp;<\/mark><\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-dark-blue-color\">Polikistik over sendromu ve ins\u00fclin direnci olan kad\u0131nlar\u0131n beslenmesi;<\/mark><\/strong><\/p>\n\n\n\n<p><strong><mark style=\"background-color:#fb0505\" class=\"has-inline-color\">1-<\/mark><\/strong>Karbonhidrat miktar\u0131 d\u00fc\u015f\u00fck, buna kar\u015f\u0131l\u0131k protein miktar\u0131 fazla olan besinleri t\u00fcketmeleri gerekir. <\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong><mark style=\"background-color:#fedb11\" class=\"has-inline-color\">\u00d6rne\u011fin; <\/mark><\/strong><\/p>\n\n\n\n<p>Baklagiller (kuru fasulye, mercimek, nohut), s\u00fct, yumurta, yo\u011furt s\u0131n\u0131rs\u0131z bir \u015fekilde t\u00fcketilebilir.<\/p>\n\n\n\n<p><strong><mark style=\"background-color:#f60909\" class=\"has-inline-color\">2-<\/mark><\/strong>Glisemik indeksi d\u00fc\u015f\u00fck olan yani kanda ins\u00fclin miktar\u0131n\u0131 h\u0131zl\u0131 bir \u015fekilde y\u00fckseltmeyen ve ayn\u0131 zamanda sindirimi yava\u015f oldu\u011fu i\u00e7in tokluk hissi yaratan lif i\u00e7eri\u011fi fazla olan karbonhidrat \u00e7e\u015fitlerini tercih etmeleri gerekir. <\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong><mark style=\"background-color:#f4f910\" class=\"has-inline-color\">\u00d6rne\u011fin;<\/mark><\/strong> <\/p>\n\n\n\n<p>Ye\u015fil sebzeler ve glisemik indeksi d\u00fc\u015f\u00fck meyveler ve \u0130ns\u00fclin direncine ba\u011fl\u0131 hiperins\u00fclinemi ortaya \u00e7\u0131kt\u0131\u011f\u0131nda hemen joker olarak tokluk hissi yaratmas\u0131 i\u00e7in t\u00fcketebilece\u011finiz bir \u00e7orba (mercimek, tarhana, tavuk suyu, yo\u011furtlu) s\u0131n\u0131rs\u0131z bir \u015fekilde t\u00fcketilebilir.<\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-dark-pink-color\">Beslenme \u015feklinin d\u00fczenlenmesi ile birlikte&nbsp;fazla kilolar\u0131n verilmesi ve verilen kilolar\u0131n kal\u0131c\u0131 bir \u015fekilde korunmas\u0131 i\u00e7in ki\u015finin g\u00fcnl\u00fck hareketini de artt\u0131rmas\u0131 gerekmektedir(38).<\/mark><\/strong><\/p>\n\n\n\n<p>D\u00fczenli olarak yap\u0131lan spor (y\u00fcr\u00fcy\u00fc\u015f gibi) kilodan ba\u011f\u0131ms\u0131z olarak yani ki\u015fi fazla kilolu olsa dahi v\u00fccutta bulunan&nbsp;ya\u011f dokusunun yerini kas dokusunun&nbsp;almas\u0131n\u0131 sa\u011flayarak ins\u00fclin direncini azaltmaktad\u0131r(38).<\/p>\n\n\n\n<p> Bu \u015fekilde ins\u00fclin direncinin azalmas\u0131 ayn\u0131 zamanda bir a\u00e7l\u0131k hormonu olan ins\u00fclin hormonunun da kanda azalmas\u0131na neden olur. Bu durum ki\u015finin i\u015ftah\u0131n\u0131 \u00f6zellikle karbonhidratlara olan iste\u011fini azaltarak uygulad\u0131\u011f\u0131 beslenme d\u00fczeninden&nbsp;sonu\u00e7 almas\u0131n\u0131 kolayla\u015ft\u0131r\u0131r.<\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-dark-pink-color\">Polikistik over sendromu olan kad\u0131nlarda ins\u00fclin direncini de\u011ferlendirmek i\u00e7in maalesef sadece yetersiz bir y\u00f6ntem olan a\u00e7l\u0131k kan \u015fekeri ve a\u00e7l\u0131k ins\u00fclin \u00f6l\u00e7\u00fcm\u00fcn\u00fcn kullan\u0131lmas\u0131 polikistik over sendromu olan bir\u00e7ok kad\u0131nda ins\u00fclin direnci veya \u015feker intolerans\u0131n\u0131n atlanmas\u0131na, g\u00f6zden ka\u00e7mas\u0131na neden olmaktad\u0131r. <\/mark><\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-dark-pink-color\">Bazen de bu durumun tam tersi olmakta yani ins\u00fclin direnci olmayan bir kad\u0131na yine a\u00e7l\u0131k kan \u015fekeri ve a\u00e7l\u0131k ins\u00fclin d\u00fczeyine bakarak \u201dsende ins\u00fclin direnci var\u201d denilerek gereksiz yere panik ve endi\u015fe yarat\u0131lmaktad\u0131r. <\/mark><\/strong><\/p>\n\n\n\n<p>Polikistik over sendromu olan kad\u0131nlarda ins\u00fclin direnci olup olmad\u0131\u011f\u0131n\u0131 m\u00fcmk\u00fcn olduk\u00e7a do\u011fru bir \u015fekilde ancak 75 gram y\u00fckleme sonras\u0131 veya tokluk 120 dk ins\u00fclin ve kan \u015fekeri \u00f6l\u00e7\u00fcmleri bize g\u00f6stermektedir.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"4- Polikistik Over ins\u00fclin direnci \u00f6l\u00e7\u00fcm\u00fc - Dr. Burak Hac\u0131hanefio\u011flu\" width=\"1320\" height=\"743\" src=\"https:\/\/www.youtube.com\/embed\/F3SvzVwTivE?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"has-text-align-center\"><strong>Kaynaklar<\/strong><\/p>\n\n\n\n<p>1-Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Dunaif A, Segal KR, Futterweit W, Dobrjansky A.&nbsp;Diabetes. 1989&nbsp;Sep;38(9):1165-74.<\/p>\n\n\n\n<p>2-Prediction models for insulin resistance in the polycystic ovary syndrome. Gennarelli G, Holte J, Berglund L, Berne C, Massobrio M, Lithell H. Hum Reprod. 2000 Oct;15(10):2098-102.<\/p>\n\n\n\n<p>3-Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. Legro RS, Kunselman AR, Dodson WC, Dunaif A. J Clin Endocrinol Metab. 1999&nbsp;Jan;84(1):165-9.<\/p>\n\n\n\n<p>4-Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Ehrmann DA, Barnes RB, Rosenfield RL, Cavaghan MK, Imperial J.&nbsp;Diabetes Care. 1999&nbsp;Jan;22(1):141-6.<\/p>\n\n\n\n<p>5-Screening for abnormal glucose tolerance in adolescents with polycystic ovary syndrome. Palmert MR, Gordon CM, Kartashov AI, Legro RS, Emans SJ, Dunaif A.&nbsp;J Clin Endocrinol Metab. 2002&nbsp;Mar;87(3):1017-23.<\/p>\n\n\n\n<p>6-Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women.&nbsp;Talbott EO, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ. J Womens Health (Larchmt). 2007 Mar;16(2):191-7.<\/p>\n\n\n\n<p>7-Relative risk of conversion from normoglycaemia to impaired glucose tolerance or non-insulin dependent diabetes mellitus in polycystic ovarian syndrome. Norman RJ, Masters L, Milner CR, Wang JX, Davies MJ.&nbsp;Hum Reprod. 2001&nbsp;Sep;16(9):1995-8.<\/p>\n\n\n\n<p>8-Glucose intolerance in a large cohort of mediterranean women with polycystic ovary syndrome: phenotype and associated factors. Gambineri A, Pelusi C, Manicardi E, Vicennati V, Cacciari M, Morselli-Labate AM, Pagotto U, Pasquali R.&nbsp;Diabetes. 2004&nbsp;Sep;53(9):2353-8.<\/p>\n\n\n\n<p>9-Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome. Carmina E&nbsp;, Lobo RA.&nbsp;Fertil Steril. 2004&nbsp;&nbsp;Sep;82(3):661-5.<\/p>\n\n\n\n<p>10-Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. DeUgarte CM, Bartolucci AA, Azziz R.&nbsp;Fertil Steril. 2005&nbsp;May;83(5):1454-60.<\/p>\n\n\n\n<p>11-Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies. Edelstein SL, Knowler WC, Bain RP, Andres R, Barrett-Connor EL, Dowse GK, Haffner SM, Pettitt DJ, Sorkin JD, Muller DC, Collins VR, Hamman RF.&nbsp;Diabetes. 1997&nbsp;&nbsp;Apr;46(4):701-10.<\/p>\n\n\n\n<p>12-Changes in glucose tolerance over time in women with polycystic ovary syndrome: a controlled study. Legro RS, Gnatuk CL, Kunselman AR, Dunaif A.&nbsp;J Clin Endocrinol Metab. 2005&nbsp;Jun;90(6):3236-42.<\/p>\n\n\n\n<p>13-Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system. Nestler JE, Jakubowicz DJ, de Vargas AF, Brik C, Quintero N, Medina F.&nbsp;J Clin Endocrinol Metab. 1998&nbsp;Jun;83(6):2001-5.<\/p>\n\n\n\n<p>14-Insulin stimulates androgen accumulation in incubations of human ovarian stroma and theca.&nbsp;Barbieri RL, Makris A, Ryan KJ.&nbsp;Obstet Gynecol. 1984 Sep;64(3 Suppl):73S-80S.<\/p>\n\n\n\n<p>15-Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. Barbieri RL, Makris A, Randall RW, Daniels G, Kistner RW, Ryan KJ.&nbsp;J Clin Endocrinol Metab. 1986 May;62(5):904-10.<\/p>\n\n\n\n<p>16-Metabolic regulation of androgen production by human thecal cells in vitro.&nbsp;Nahum R, Thong KJ, Hillier SG.&nbsp;Hum Reprod. 1995 Jan;10(1):75-81.<\/p>\n\n\n\n<p>17-Regulation of androgen production in cultured human thecal cells&nbsp;by insulin-like growth factor I and insulin. Bergh C&nbsp;, Carlsson B, Olsson JH, Selleskog U, Hillensj\u00f6 T.&nbsp;Fertil Steril. 1993 Feb;59(2):323-31.<\/p>\n\n\n\n<p>18-Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries.&nbsp;Gilling-Smith C, Willis DS, Beard RW, Franks S.&nbsp;J Clin Endocrinol Metab. 1994 Oct;79(4):1158-65.<\/p>\n\n\n\n<p>19-Insulin action in the normal and polycystic ovary.&nbsp;Franks S, Gilling-Smith C, Watson H, Willis D.&nbsp;Endocrinol Metab Clin North Am. 1999 Jun;28(2):361-78.<\/p>\n\n\n\n<p>20-Hyperinsulinemia amplifies GnRH agonist stimulated&nbsp;ovarian steroid secretion&nbsp;in women with polycystic ovary syndrome.&nbsp;Tosi F, Negri C, Perrone F, Dorizzi R, Castello R, Bonora E, Moghetti P.&nbsp;J Clin Endocrinol Metab. 2012 May;97(5):1712-9.<\/p>\n\n\n\n<p>21-Oestradiol feedback stimulation of androgen&nbsp;biosynthesis by human theca cells.&nbsp;Gilling-Smith C, Willis DS, Franks S.&nbsp;Hum Reprod. 1997 Aug;12(8):1621-8.<\/p>\n\n\n\n<p>22-Secretion of testosterone-estradiol-binding globulin by a human hepatoma-derived cell line. Khan MS, Knowles BB, Aden DP, Rosner W.&nbsp;J Clin Endocrinol Metab. 1981&nbsp;Aug;53(2):448-9.<\/p>\n\n\n\n<p>23-Molecular properties of corticosteroid binding globulin and the sex-steroid binding proteins. Hammond GL.&nbsp;Endocr Rev. 1990&nbsp;Feb;11(1):65-79.<\/p>\n\n\n\n<p>24-Regulation of production and secretion of sex hormone-binding globulin in HepG2 cell cultures by hormones and growth factors.&nbsp;Loukovaara M, Carson M, Adlercreutz H. J Clin Endocrinol Metab. 1995&nbsp;Jan;80(1):160-4.<\/p>\n\n\n\n<p>25-Modulation by insulin of follicle-stimulating hormone and luteinizing hormone actions in human granulosa cells of normal and polycystic ovaries. Willis D, Mason H, Gilling- Smith C, Franks S. J Clin Endocrinol Metab. 1996 Jan;81(1):302-9.<\/p>\n\n\n\n<p>26-Differential effects of insulin sensitivity on androgens in obese women with polycystic ovary syndrome or normal ovulation. Asagami T, Holmes TH, Reaven G.&nbsp;Metabolism. 2008&nbsp;Oct;57(10):1355-60.<\/p>\n\n\n\n<p>27-Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis.&nbsp;Hum Reprod Update. Moran LJ, Misso ML, Wild RA, Norman RJ. 2010&nbsp;Jul-Aug;16(4):347-63.<\/p>\n\n\n\n<p>28-Circulating levels of adipose products and differences in fat distribution in the ovulatory and anovulatory phenotypes of polycystic ovary syndrome. Carmina E, Bucchieri S, Mansueto P, Rini G, Ferin M, Lobo RA.&nbsp;Fertil Steril. 2009&nbsp;Apr;91(4 Suppl):1332-5.<\/p>\n\n\n\n<p>29-Body composition characteristics and body fat distribution in lean women with polycystic ovary syndrome. Kirchengast S, Huber J. Hum Reprod. 2001&nbsp;Jun;16(6):1255-60.<\/p>\n\n\n\n<p>30-Abdominal fat quantity and distribution in women with polycystic ovary syndrome and extent of its relation to insulin resistance. Carmina E, Bucchieri S, Esposito A, Del Puente A, Mansueto P, Orio F, Di Fede G, Rini G.&nbsp;J Clin Endocrinol Metab. 2007&nbsp;Jul;92(7):2500-5.<\/p>\n\n\n\n<p>31-Insulin resistance and polycystic ovary syndrome through life.&nbsp;Diamanti-Kandarakis E, Spritzer PM, Sir-Petermann T, Motta AB.&nbsp;Curr Pharm Des. 2012;18(34):5569-76.<\/p>\n\n\n\n<p>32-Treatment of obesity in polycystic ovary syndrome: a position statement of the Androgen Excess and Polycystic Ovary Syndrome Society. Moran LJ,&nbsp;Pasquali R, Teede HJ, Hoeger KM, Norman RJ. Fertil Steril. 2009&nbsp;Dec;92(6):1966-82.<\/p>\n\n\n\n<p>33-Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. Moghetti P, Castello R, Negri C, Tosi F, Perrone F, Caputo M, Zanolin E, Muggeo M. J Clin Endocrinol Metab. 2000&nbsp;Jan;85(1):139-46.<\/p>\n\n\n\n<p>34-Insulin-lowering agents in the management of polycystic ovary syndrome.&nbsp;De Leo V, la Marca A, Petraglia F.&nbsp;Endocr Rev. 2003&nbsp;Oct;24(5):633-67.<\/p>\n\n\n\n<p>35-When should an insulin sensitizing agent be used in the treatment of polycystic ovary syndrome?Franks S.&nbsp;Clin Endocrinol (Oxf). 2011&nbsp;Feb;74(2):148-51.<\/p>\n\n\n\n<p>36-Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome. A randomized, placebo-controlled, double-blind multicentre study. Tang T, Glanville J, Hayden CJ, White D, Barth JH, Balen AH.&nbsp;Hum Reprod. 2006&nbsp;Jan;21(1):80-9.<\/p>\n\n\n\n<p>37-American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation andTreatment of Polycystic Ovary Syndrome-Part 2. Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society.&nbsp;Endocr Pract. 2015 Dec;21(12):1415-1426.<\/p>\n\n\n\n<p>38-Lifestyle changes in women with polycystic ovary syndrome.&nbsp;Moran LJ, Hutchison SK, Norman RJ, Teede HJ.&nbsp;Cochrane Database Syst Rev. 2011 Jul 6;(7):CD007506.<\/p>\n\n\n\n<p>39-Follicle dynamics and anovulation in polycystic ovary syndrome. Franks S, Stark J, Hardy K.&nbsp;Hum Reprod Update. 2008&nbsp;Jul-Aug;14(4):367-78.<\/p>\n\n\n\n<p>40-Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome. Cadagan D, Khan R, Amer S.&nbsp;Reprod Biol. 2016&nbsp;Mar;16(1):53-60.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Polikistik over sendromu\u2019nda fazla kilolu ve \u015fi\u015fman olan veya normal kilolu fakat bel \u00e7evresi kal\u0131n&nbsp;(erkek tipi ya\u011flanma) olan kad\u0131nlar\u0131n b\u00fcy\u00fck \u00e7o\u011funlu\u011funda&nbsp;ins\u00fclin direnci&nbsp; g\u00f6r\u00fclmektedir(1,2,9,10). Polikistik over sendromu olan normal kilolu veya zay\u0131f ya da fazla kilolu veya&nbsp;\u015fi\u015fman kad\u0131nlar\u0131n bir k\u0131sm\u0131nda kar\u0131n ve bel \u00e7evresinde&nbsp;ya\u011f miktar\u0131 fazla (erkek tipi ya\u011flanma)&nbsp;oldu\u011fu i\u00e7in ins\u00fclin direncinin bir g\u00f6stergesi olan bel [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6132","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/6132","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/comments?post=6132"}],"version-history":[{"count":34,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/6132\/revisions"}],"predecessor-version":[{"id":12848,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/6132\/revisions\/12848"}],"wp:attachment":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/media?parent=6132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}