{"id":6881,"date":"2025-09-21T12:47:03","date_gmt":"2025-09-21T12:47:03","guid":{"rendered":"https:\/\/polikistikover.net\/yeni\/?page_id=6881"},"modified":"2025-10-25T01:52:12","modified_gmt":"2025-10-25T01:52:12","slug":"polikistik-over-sendromunda-cilt-renginde-koyulasma-ve-et-benleri","status":"publish","type":"page","link":"https:\/\/polikistikover.net\/yeni\/polikistik-over-sendromunda-cilt-renginde-koyulasma-ve-et-benleri\/","title":{"rendered":"Polikistik Over Sendromu\u2019nda Cilt Renginde Koyula\u015fma ve Et Benleri"},"content":{"rendered":"\n

Polikistik over sendromu\u2019nda fazla kilolu ve \u015fi\u015fman olan veya normal kilolu fakat bel \u00e7evresi kal\u0131n (erkek tipi ya\u011flanma) olan kad\u0131nlar\u0131n b\u00fcy\u00fck \u00e7o\u011funlu\u011funda ins\u00fclin direnci <\/a>g\u00f6r\u00fclmektedir(1,2,3,4).<\/strong><\/mark><\/p>\n\n\n\n

Polikistik over sendromu olan normal kilolu veya zay\u0131f ya da fazla kilolu veya \u015fi\u015fman kad\u0131nlar\u0131n bir k\u0131sm\u0131nda kar\u0131n ve bel \u00e7evresinde ya\u011f miktar\u0131 fazla <\/a>(erkek tipi ya\u011flanma) oldu\u011fu i\u00e7in ins\u00fclin direncinin bir g\u00f6stergesi olan bel \u00e7evresi kal\u0131nl\u0131\u011f\u0131 g\u00f6r\u00fclmektedir(5,6,7,8).<\/p>\n\n\n

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\"\"<\/figure>\n<\/div>\n\n\n

Polikistik over sendromu olan fazla kilolu kad\u0131nlarda boyun, kas\u0131k ve koltuk alt\u0131 b\u00f6lgelerinde renk koyula\u015fmas\u0131 (siyahla\u015fma) ve kal\u0131nla\u015fma ortaya \u00e7\u0131kabilir. Buna Akantozis Nigrikans (AN) denilmektedir(13).<\/mark><\/strong><\/p>\n\n\n\n

Akantozis Nigrikans (AN) ins\u00fclin direnci ve ins\u00fclinin fazla salg\u0131lanmas\u0131ndan kaynaklanmakta olup glukoz ve ins\u00fclin metabolizmas\u0131ndaki bozuklu\u011fu yans\u0131tmaktad\u0131r<\/strong>.<\/mark><\/p>\n\n\n

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\"\"<\/figure>\n<\/div>\n\n\n

Tedavi; <\/strong><\/p>\n\n\n\n

Tedavinin amac\u0131 ins\u00fclin direncine kar\u015f\u0131 \u201d\u0130ns\u00fclin duyarl\u0131l\u0131\u011f\u0131\u201dn\u0131n artt\u0131r\u0131lmas\u0131d\u0131r(9,10,11,12). \u0130ns\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131n artmas\u0131 ile birlikte ins\u00fclin direnci azal\u0131r. \u0130ns\u00fclin direncinin azalmas\u0131 sonucunda pankreas daha az ins\u00fclin \u00fcretmeye ba\u015flar. \u0130ns\u00fclin hormonunun normal seviyelere d\u00fc\u015f\u00fcr\u00fclmesi sonucunda bu renk koyula\u015fmas\u0131 (siyahla\u015fma) kaybolmaktad\u0131r.<\/p>\n\n\n\n

Boyun, kas\u0131k, koltuk alt\u0131 ve g\u00f6\u011f\u00fcs alt\u0131 gibi s\u00fcrt\u00fcnmenin fazla oldu\u011fu b\u00f6lgelerde g\u00f6r\u00fclen deriye sapla ba\u011fl\u0131 et benleri (Skin Tags) (acrochordon) ins\u00fclin hormonunun fazla salg\u0131lanmas\u0131ndan kaynaklanmakta olup \u015feker hastal\u0131\u011f\u0131n\u0131n \u00f6nc\u00fc bir belirtisidir.<\/mark><\/strong><\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

Polikistik over sendromu\u2019nda fazla kilolu ve \u015fi\u015fman olan veya normal kilolu fakat bel \u00e7evresi kal\u0131n (erkek tipi ya\u011flanma) olan kad\u0131nlar\u0131n b\u00fcy\u00fck \u00e7o\u011funlu\u011funda ins\u00fclin direnci oldu\u011fu i\u00e7in boyun, ense, kas\u0131k, koltuk alt\u0131 ve g\u00f6\u011f\u00fcs alt\u0131nda deriye sapla ba\u011fl\u0131 et benleri (Skin Tags) (acrochordon) daha \u00e7ok g\u00f6r\u00fclmektedir.<\/p>\n\n\n\n

Tedavi; <\/strong><\/p>\n\n\n\n

Tedavinin amac\u0131 ins\u00fclin direncine kar\u015f\u0131\u00a0\u201d\u0130ns\u00fclin duyarl\u0131l\u0131\u011f\u0131\u201dn\u0131n artt\u0131r\u0131lmas\u0131d\u0131r(9,10,11,12). \u0130ns\u00fclin direncinin azalt\u0131lmas\u0131 ve ins\u00fclin direncine ba\u011fl\u0131 olarak fazla miktarda \u00fcretilen ins\u00fclin hormonunun normal seviyelere d\u00fc\u015f\u00fcr\u00fclmesidir.<\/p>\n\n\n\n

Kaynaklar<\/strong><\/p>\n\n\n\n

1-Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Dunaif A, Segal KR, Futterweit W, Dobrjansky A. Diabetes. 1989 Sep;38(9):1165-74.<\/p>\n\n\n\n

2-Prediction models for insulin resistance in the polycystic ovary syndrome. Gennarelli G, Holte J, Berglund L, Berne C, Massobrio M, Lithell H. Hum Reprod. 2000 Oct;15(10):2098-102.<\/p>\n\n\n\n

3-Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome. carmina E , Lobo RA. Fertil Steril. 2004  Sep;82(3):661-5.<\/p>\n\n\n\n

4-Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. DeUgarte CM, Bartolucci AA, Azziz R. Fertil Steril. 2005 May;83(5):1454-60.<\/p>\n\n\n\n

5-Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. Moran LJ, Misso ML, Wild RA, Norman RJ. 2010 Jul-Aug;16(4):347-63.<\/p>\n\n\n\n

6-Circulating levels of adipose products and differences in fat distribution in the ovulatory and anovulatory phenotypes of polycystic ovary syndrome. Carmina E, Bucchieri S, Mansueto P, Rini G, Ferin M, Lobo RA. Fertil Steril. 2009 Apr;91(4 Suppl):1332-5.<\/p>\n\n\n\n

7-Body composition characteristics and body fat distribution in lean women with polycystic ovary syndrome. Kirchengast S, Huber J. Hum Reprod. 2001 Jun;16(6):1255-60.<\/p>\n\n\n\n

8-Abdominal fat quantity and distribution in women with polycystic ovary syndrome and extent of its relation to insulin resistance. Carmina E, Bucchieri S, Esposito A, Del Puente A, Mansueto P, Orio F, Di Fede G, Rini G. J Clin Endocrinol Metab. 2007 Jul;92(7):2500-5.<\/p>\n\n\n\n

9-Insulin resistance and polycystic ovary syndrome through life. Diamanti-Kandarakis E, Spritzer PM, Sir-Petermann T, Motta AB. Curr Pharm Des. 2012;18(34):5569-76.<\/p>\n\n\n\n

10-Treatment of obesity in polycystic ovary syndrome: a position statement of the Androgen Excess and Polycystic Ovary Syndrome Society. Moran LJ, Pasquali R, Teede HJ, Hoeger KM, Norman RJ. Fertil Steril. 2009 Dec;92(6):1966-82.<\/p>\n\n\n\n

11-Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. Moghetti P, Castello R, Negri C, Tosi F, Perrone F, Caputo M, Zanolin E, Muggeo M. J Clin Endocrinol Metab. 2000 Jan;85(1):139-46.<\/p>\n\n\n\n

12-Insulin-lowering agents in the management of polycystic ovary syndrome. De Leo V, la Marca A, Petraglia F. Endocr Rev. 2003 Oct;24(5):633-67.
13-Acanthosis nigricans in obese women with the polycystic ovary syndrome: disease spectrum not distinct entity. G. S. Conway and H. S. Jacobs. Postgrad Med J. 1990 Jul; 66(777): 536\u2013538.<\/p>\n","protected":false},"excerpt":{"rendered":"

Polikistik over sendromu\u2019nda fazla kilolu ve \u015fi\u015fman olan veya normal kilolu fakat bel \u00e7evresi kal\u0131n (erkek tipi ya\u011flanma) olan kad\u0131nlar\u0131n b\u00fcy\u00fck \u00e7o\u011funlu\u011funda ins\u00fclin direnci g\u00f6r\u00fclmektedir(1,2,3,4). Polikistik over sendromu olan normal kilolu veya zay\u0131f ya da fazla kilolu veya \u015fi\u015fman kad\u0131nlar\u0131n bir k\u0131sm\u0131nda kar\u0131n ve bel \u00e7evresinde ya\u011f miktar\u0131 fazla (erkek tipi ya\u011flanma) oldu\u011fu i\u00e7in ins\u00fclin direncinin bir g\u00f6stergesi olan bel […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6881","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/6881","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/comments?post=6881"}],"version-history":[{"count":20,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/6881\/revisions"}],"predecessor-version":[{"id":10299,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/6881\/revisions\/10299"}],"wp:attachment":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/media?parent=6881"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}