{"id":7949,"date":"2025-09-27T19:35:31","date_gmt":"2025-09-27T19:35:31","guid":{"rendered":"https:\/\/polikistikover.net\/yeni\/?page_id=7949"},"modified":"2025-11-25T01:11:22","modified_gmt":"2025-11-25T01:11:22","slug":"sigara-ve-polikistik-over-2","status":"publish","type":"page","link":"https:\/\/polikistikover.net\/yeni\/sigara-ve-polikistik-over-2\/","title":{"rendered":"Sigara ve Polikistik Over"},"content":{"rendered":"\n

Polikistik over sendromu\u2019nda fazla kilolu veya \u015fi\u015fman ya da normal kilolu, hatta zay\u0131f, fakat kar\u0131n ve bel \u00e7evresinde ya\u011f miktar\u0131 fazla (erkek tipi ya\u011flanma) olan kad\u0131nlarda ins\u00fclin direnci g\u00f6r\u00fclmektedir(1,2,3,4).<\/mark><\/strong><\/p>\n\n\n\n

Sigarada bulunan nikotin de ins\u00fclin direncine neden olmaktad\u0131r. <\/mark>(5,6,7,8,9,10)<\/mark><\/strong>;<\/p>\n\n\n\n

Sigaran\u0131n kilo almay\u0131 \u00f6nleyici etkisi nedeniyle fazla kilolu olmayan sigara i\u00e7en bu kad\u0131nlar\u0131n bel ve kar\u0131n b\u00f6lgesinde ins\u00fclin direncinin belirtisi olan erkek tipi ya\u011flanma art\u0131\u015f\u0131 g\u00f6r\u00fclmektedir(11). <\/mark><\/strong><\/p>\n\n\n\n

Sigara kullanan polikistik over sendromu olan kad\u0131nlarda kilo art\u0131\u015f\u0131 olmasa bile kar\u0131n ve bel \u00e7evresinde ya\u011f miktar\u0131 fazlal\u0131\u011f\u0131 ve ins\u00fclin direnci artmaktad\u0131r(11,12,13,14,15).<\/mark><\/strong><\/p>\n\n\n\n

Polikistik over sendromu olan ve sigara i\u00e7en kad\u0131nlarda sigarada bulunan nikotin, erkeklik hormonlar\u0131n\u0131n (testosteron) etkisiz maddelere (metabolit) d\u00f6n\u00fc\u015ferek v\u00fccuttan at\u0131lmas\u0131n\u0131 engellemektedir(16,17);<\/mark><\/strong><\/p>\n\n\n\n

Bu nedenle sigara kullanan polikistik over sendromu olan kad\u0131nlarda testosteron miktar\u0131 daha da artmaktad\u0131r(18,19,20).<\/mark><\/strong><\/p>\n\n\n\n

Kaynaklar<\/strong><\/p>\n\n\n\n

1-Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Dunaif A, Segal KR, Futterweit W, Dobrjansky A. Diabetes. 1989 Sep;38(9):1165-74.<\/p>\n\n\n\n

2-Prediction models for insulin resistance in the polycystic ovary syndrome. Gennarelli G, Holte J, Berglund L, Berne C, Massobrio M, Lithell H. Hum Reprod. 2000 Oct;15(10):2098-102.<\/p>\n\n\n\n

3-Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome. carmina E , Lobo RA. Fertil Steril. 2004 Sep;82(3):661-5.<\/p>\n\n\n\n

4-Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. DeUgarte CM, Bartolucci AA, Azziz R. Fertil Steril. 2005 May;83(5):1454-60.<\/p>\n\n\n\n

5-Smoking induces insulin resistance\u2013a potential link with the insulin resistance syndrome. Attvall S, Fowelin J, Lager I, Von Schenck H, Smith U. J Intern Med. 1993 Apr;233(4):327-32.<\/p>\n\n\n\n

6-Insulin resistance and cigarette smoking. Facchini FS, Hollenbeck CB, Jeppesen J, Chen YD, Reaven GM. Lancet. 1992 May 9;339(8802):1128-30.<\/p>\n\n\n\n

7-Cigarette Smoking: An Accessory to the Development of Insulin Resistance. Artese A, Stamford BA, Moffatt RJ. Am J Lifestyle Med. 2017 Aug 23;13(6):602-605.<\/p>\n\n\n\n

8-Chronic Tobacco Exposure by Smoking Develops Insulin Resistance. Mukharjee S, Bank S, Maiti S. Endocr Metab Immune Disord Drug Targets. 2020;20(6):869-877.<\/p>\n\n\n\n

9-Intramuscular lipid metabolism in the insulin resistance of smoking. Bergman BC, Perreault L, Hunerdosse DM, Koehler MC, Samek AM, Eckel RH. Diabetes. 2009 Oct;58(10):2220-7.<\/p>\n\n\n\n

10-Novel and reversible mechanisms of smoking-induced insulin resistance in humans. Bergman BC, Perreault L, Hunerdosse D, Kerege A, Playdon M, Samek AM, Eckel RH.Diabetes. 2012 Dec;61(12):3156-66.<\/p>\n\n\n\n

11-Cigarette smoking and fat distribution in 21,828 British men and women: a population-based study. Canoy D, Wareham N, Luben R, Welch A, Bingham S, Day N, Khaw KT.Obes Res. 2005 Aug;13(8):1466-75.<\/p>\n\n\n\n

12-Circulating levels of adipose products and differences in fat distribution in the ovulatory and anovulatory phenotypes of polycystic ovary syndrome. Carmina E, Bucchieri S, Mansueto P, Rini G, Ferin M, Lobo RA. Fertil Steril. 2009 Apr;91(4 Suppl):1332-5.<\/p>\n\n\n\n

13-Body composition characteristics and body fat distribution in lean women with polycystic ovary syndrome. Kirchengast S, Huber J. Hum Reprod. 2001 Jun;16(6):1255-60.<\/p>\n\n\n\n

14-Abdominal fat quantity and distribution in women with polycystic ovary syndrome and extent of its relation to insulin resistance. Carmina E, Bucchieri S, Esposito A, Del Puente A, Mansueto P, Orio F, Di Fede G, Rini G. J Clin Endocrinol Metab. 2007 Jul;92(7):2500-5.<\/p>\n\n\n\n

15-Nicotinic regulation of energy homeostasis. Zoli M, Picciotto MR.Nicotine Tob Res. 2012 Nov;14(11):1270-90.<\/p>\n\n\n\n

16-Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms. Chen G, Giambrone NE Jr, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P.Cancer Res. 2010 Oct 1;70(19):7543-52.<\/p>\n\n\n\n

17-Smoking, sex, risk factors and abdominal aortic aneurysm: is it all down to testosterone? Schooling CM. J Epidemiol Community Health. 2015 May;69(5):495.<\/p>\n\n\n\n

18-Cigarette smoking and testosterone in men and women: A systematic review and meta-analysis of observational studies. Zhao J, Leung JYY, Lin SL, Mary Schooling C. Prev Med. 2016 Apr;85:1-10.<\/p>\n\n\n\n

19-Smoking in infertile women with polycystic ovary syndrome: baseline validation of self-report and effects on phenotype. Legro RS, Chen G, Kunselman AR, Schlaff WD, Diamond MP, Coutifaris C, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers ER, Zhang H, Foulds J; Reproductive Medicine Network. Hum Reprod. 2014 Dec;29(12):2680-6.<\/p>\n\n\n\n

20-Effect of exposure to second-hand smoke from husbands on biochemical hyperandrogenism, metabolic syndrome and conception rates in women with polycystic ovary syndrome undergoing ovulation induction. Li J, Wu Q, Wu XK, Zhou ZM, Fu P, Chen XH, Yan Y, Wang X, Yang ZW, Li WL, Stener-Victorin E, Legro RS, Ng EH, Zhang H, Mol BWJ, Wang CC; for PCOSAct Study Group. Hum Reprod. 2018 Apr 1;33(4):617-625.<\/p>\n","protected":false},"excerpt":{"rendered":"

Polikistik over sendromu\u2019nda fazla kilolu veya \u015fi\u015fman ya da normal kilolu, hatta zay\u0131f, fakat kar\u0131n ve bel \u00e7evresinde ya\u011f miktar\u0131 fazla (erkek tipi ya\u011flanma) olan kad\u0131nlarda ins\u00fclin direnci g\u00f6r\u00fclmektedir(1,2,3,4). Sigarada bulunan nikotin de ins\u00fclin direncine neden olmaktad\u0131r. (5,6,7,8,9,10); Sigaran\u0131n kilo almay\u0131 \u00f6nleyici etkisi nedeniyle fazla kilolu olmayan sigara i\u00e7en bu kad\u0131nlar\u0131n bel ve kar\u0131n b\u00f6lgesinde […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7949","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/7949","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/comments?post=7949"}],"version-history":[{"count":5,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/7949\/revisions"}],"predecessor-version":[{"id":11141,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/7949\/revisions\/11141"}],"wp:attachment":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/media?parent=7949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}