{"id":8033,"date":"2025-09-27T20:32:05","date_gmt":"2025-09-27T20:32:05","guid":{"rendered":"https:\/\/polikistikover.net\/yeni\/?page_id=8033"},"modified":"2025-11-23T01:36:03","modified_gmt":"2025-11-23T01:36:03","slug":"polikistik-over-sendromu-ve-rahim-kanseri","status":"publish","type":"page","link":"https:\/\/polikistikover.net\/yeni\/polikistik-over-sendromu-ve-rahim-kanseri\/","title":{"rendered":"Polikistik Over Sendromu ve Rahim Kanseri"},"content":{"rendered":"\n

 Human Papilloma Vir\u00fcs (HPV) enfeksiyonunun neden oldu\u011fu rahim a\u011fz\u0131 (serviks) kanserinin polikistik over sendromu ile bir ili\u015fkisi yoktur.<\/mark><\/strong><\/p>\n\n\n\n

Rahim a\u011fz\u0131 kanseri polikistik over sendromu olan kad\u0131nlarda di\u011fer kad\u0131nlarda g\u00f6r\u00fcld\u00fc\u011f\u00fcnden daha \u00e7ok g\u00f6r\u00fclmemektedir.<\/mark><\/strong><\/p>\n\n\n\n

Rahim i\u00e7 tabakas\u0131 (endometriyum) kanseri polikistik over sendromu olan kad\u0131nlar\u0131n bir k\u0131sm\u0131nda g\u00f6r\u00fclen kilo fazlal\u0131\u011f\u0131, \u015fi\u015fmanl\u0131k, ins\u00fclin direnci, \u015feker hastal\u0131\u011f\u0131 ve adetlerin gecikmesi ve uzun s\u00fcre adet olamama durumlar\u0131 ile ili\u015fkilidir(1,2,3).<\/mark><\/strong><\/p>\n\n\n\n

Bu nedenle rahim i\u00e7 tabakas\u0131 kanseri polikistik over sendromu olan kad\u0131nlar\u0131n bir k\u0131sm\u0131nda daha fazla g\u00f6r\u00fclmektedir(4,5,6).<\/p>\n\n\n\n

Polikistik over sendromu\u2019nda iki  neden rahim i\u00e7 tabakas\u0131 (endometriyum) kanseri ihtimalini artt\u0131rmaktad\u0131r;<\/mark><\/strong><\/p>\n\n\n\n

1-<\/mark><\/strong>Normal bir adet d\u00f6ng\u00fcs\u00fcnde \u00f6strojen hormonu adet kanamas\u0131nda vajinadan d\u0131\u015far\u0131 at\u0131lacak olan rahim i\u00e7 tabakas\u0131n\u0131n (endometriyum) kal\u0131nla\u015fmas\u0131n\u0131 sa\u011flar.<\/p>\n\n\n\n

Yumurtlamadan sonra \u00fcretilen progesteron hormonu da bu kal\u0131nla\u015fan tabakay\u0131 adet kanamas\u0131 ile birlikte d\u0131\u015far\u0131 atarak rahim i\u00e7 zar\u0131n\u0131n tekrar incelmesine neden olur.<\/p>\n\n\n\n

Polikistik over sendromu olan kad\u0131nlar\u0131n bir b\u00f6l\u00fcm\u00fcnde yumurtlama olmad\u0131\u011f\u0131 i\u00e7in progesteron hormonu \u00fcretilemez. <\/p>\n\n\n\n

Bu nedenle g\u00f6r\u00fclen uzun s\u00fcre adet olamama durumu rahim i\u00e7 tabakas\u0131n\u0131n fazla miktarda kal\u0131nla\u015fmas\u0131na neden olur(7). <\/p>\n\n\n\n

Burada \u201duzun s\u00fcre adet olamama\u201d derken  polikistik over sendromu olan kad\u0131nlar\u0131n \u00e7o\u011funda g\u00f6r\u00fclen 10-15 g\u00fcnl\u00fck gecikmeler kastedilmemektedir. <\/p>\n\n\n\n

Rahim i\u00e7 tabakas\u0131 kal\u0131nla\u015fmas\u0131na ba\u011fl\u0131 g\u00f6r\u00fclen kanser \u00e7o\u011funlukla 6-12 ayda bir adet kanamas\u0131 olan veya adet kanamas\u0131 hi\u00e7 olmayan polikistik over sendromu olan kad\u0131nlarda kar\u015f\u0131m\u0131za \u00e7\u0131kmakla birlikte nadiren \u00e7ok az adet d\u00fczensizli\u011fi olan veya adet d\u00fczensizli\u011fi olmayan fazla kilolu, \u015fi\u015fman ve ins\u00fclin direnci olan kad\u0131nlarda da g\u00f6r\u00fclebilmektedir(12).<\/p>\n\n\n\n

\u00a02-<\/mark><\/strong>Polikistik over sendromu olan fazla kilolu veya \u015fi\u015fman kad\u0131nlarda kar\u0131n ve bel b\u00f6lgesinde biriken ya\u011f dokusunda erkeklik hormonlar\u0131 \u00f6zellikle androstenedione rahim i\u00e7 tabakas\u0131n\u0131 kal\u0131nla\u015ft\u0131ran \u00f6strojen hormonuna d\u00f6n\u00fc\u015fmektedir(8).<\/p>\n\n\n\n

\u0130ns\u00fclin direnci olanlarda fazla miktarda \u00fcretilen ins\u00fclin hormonu\u00a0\u00f6strojen hormonunu ba\u011flayarak onu etkisiz hale getiren karaci\u011ferde \u00fcretilen\u00a0sex hormon binding globulin (SHBG)\u00a0miktar\u0131n\u0131\u00a0azaltmaktad\u0131r\u00a0(8,9). SHBG azald\u0131\u011f\u0131 i\u00e7in rahim i\u00e7 tabakas\u0131n\u0131 kal\u0131nla\u015ft\u0131ran\u00a0serbest dola\u015fan \u00f6strojen miktar\u0131 artmaktad\u0131r\u00a0(10). <\/p>\n\n\n\n

\u0130ns\u00fclin hormonu ayn\u0131 zamanda yumurtal\u0131kta \u00f6strojen hormonuna d\u00f6n\u00fc\u015fen erkeklik hormonlar\u0131ndan testosteron ve ya\u011f dokusunda \u00f6strojen hormonuna d\u00f6n\u00fc\u015fen androstenedione \u00fcretimini artt\u0131rmaktad\u0131r(11). <\/p>\n\n\n\n

Bu durum \u00f6strojen hormonu \u00fcretiminin daha fazla artmas\u0131na neden olmaktad\u0131r. \u00d6strojen hormonu \u00fcretiminin artmas\u0131na ba\u011fl\u0131 olarak rahim i\u00e7 tabakas\u0131 (endometriyum) daha fazla kal\u0131nla\u015fmaktad\u0131r.<\/p>\n\n\n\n

Kal\u0131nla\u015fan rahim i\u00e7 tabakas\u0131n\u0131n d\u00f6k\u00fclerek at\u0131lmas\u0131 sonucunda bu ki\u015filerde;<\/mark><\/strong><\/p>\n\n\n\n

1-<\/mark><\/strong> uzun s\u00fcre devam eden, fazla miktarda, koyu renkli, p\u0131ht\u0131l\u0131 kanamalar,<\/p>\n\n\n\n

2-<\/mark><\/strong>uzun s\u00fcre devam eden az miktarlarda (lekelenme) adet kanamalar\u0131 g\u00f6r\u00fclebilmektedir.<\/p>\n\n\n\n

Bu \u015fekilde kanamalara neden olan rahim i\u00e7 zar\u0131 kal\u0131nla\u015fmalar\u0131n\u0131n hepsi rahim i\u00e7 tabakas\u0131 kanseri anlam\u0131na gelmemektedir.<\/mark><\/strong><\/p>\n\n\n\n

Her rahim i\u00e7 tabakas\u0131 kal\u0131nla\u015fmas\u0131 kansere d\u00f6n\u00fc\u015fmemektedir. Bunlar\u0131n ancak bir k\u0131sm\u0131nda rahim i\u00e7 tabakas\u0131 kanseri ortaya \u00e7\u0131kmaktad\u0131r.<\/mark><\/strong><\/p>\n\n\n\n

Kaynaklar<\/strong><\/p>\n\n\n\n

1-Anthropometry, physical activity, and endometrial cancer risk: results from the Netherlands Cohort Study. Schouten, L.J., R.A. Goldbohm, and P.A. van den Brandt. J Natl Cancer Inst, 2004. 96(21): p. 1635-8.<\/p>\n\n\n\n

2-Zhao, J., et al., Effects of insulin on proliferation and apoptosis of endometrial carcinoma cell. Zhonghua Fu Chan Ke Za Zhi, 2007. 42(10): p. 696-700.<\/p>\n\n\n\n

3-Gunter, M.J., et al., A prospective evaluation of insulin and insulin-like growth factor-I as risk factors for endometrial cancer. Cancer Epidemiol Biomarkers Prev, 2008. 17(4): p. 921-9.<\/p>\n\n\n\n

4-Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis. Barry JA, Azizia MM, Hardiman PJ. Hum Reprod Update. 2014 Sep-Oct;20(5):748-58.<\/p>\n\n\n\n

5-Polycystic ovary syndrome and endometrial carcinoma. Hardiman P, Pillay OC, Atiomo W.Lancet. 2003 May 24;361(9371):1810-2.<\/p>\n\n\n\n

6-Evaluating the association between endometrial cancer and polycystic ovary syndrome. Haoula Z, Salman M, Atiomo W. Hum Reprod. 2012 May;27(5):1327-31.<\/p>\n\n\n\n

7-Case-control study of endogenous steroid hormones and endometrial cancer. Potischman N et al. J Nath Cancer Inst. 1996 Aug 21;88(16):1127-35.<\/p>\n\n\n\n

8-Regulation of sex hormone binding globulin (SHBG) production in Hep G2 cells by insulin. Plymate, S.R., et al. Steroids, 1988. 52(4): p. 339-40.<\/p>\n\n\n\n

9-A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome.Nestler, J.E., et al. J Clin Endocrinol Metab, 1991. 72(1): p. 83-9.<\/p>\n\n\n\n

10-Differences in free estradiol and sex hormone-binding globulin in women with and without premenstrual dysphoric disorder.Thys-Jacobs S, McMahon D, Bilezikian JP. J Clin Endocrinol Metab. 2008 Jan;93(1):96-102.<\/p>\n\n\n\n

11-Peripheral aromatization as a risk factor for breast and endometrial cancer in postmenopausal women: a review. Enriori CL, Reforzo-Membrives J. Gynecol Oncol. 1984 Jan;17(1):1-21.<\/p>\n\n\n\n

12-Ultrasound and menstrual history in predicting endometrial hyperplasia in polycystic ovary syndrome. Cheung AP. Obstet Gynecol. 2001 Aug;98(2):325-31.<\/p>\n","protected":false},"excerpt":{"rendered":"

 Human Papilloma Vir\u00fcs (HPV) enfeksiyonunun neden oldu\u011fu rahim a\u011fz\u0131 (serviks) kanserinin polikistik over sendromu ile bir ili\u015fkisi yoktur. Rahim a\u011fz\u0131 kanseri polikistik over sendromu olan kad\u0131nlarda di\u011fer kad\u0131nlarda g\u00f6r\u00fcld\u00fc\u011f\u00fcnden daha \u00e7ok g\u00f6r\u00fclmemektedir. Rahim i\u00e7 tabakas\u0131 (endometriyum) kanseri polikistik over sendromu olan kad\u0131nlar\u0131n bir k\u0131sm\u0131nda g\u00f6r\u00fclen kilo fazlal\u0131\u011f\u0131, \u015fi\u015fmanl\u0131k, ins\u00fclin direnci, \u015feker hastal\u0131\u011f\u0131 ve adetlerin gecikmesi ve uzun s\u00fcre adet olamama durumlar\u0131 ile ili\u015fkilidir(1,2,3). Bu nedenle […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8033","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8033","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/comments?post=8033"}],"version-history":[{"count":9,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8033\/revisions"}],"predecessor-version":[{"id":12927,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8033\/revisions\/12927"}],"wp:attachment":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/media?parent=8033"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}