{"id":8053,"date":"2025-09-27T20:45:46","date_gmt":"2025-09-27T20:45:46","guid":{"rendered":"https:\/\/polikistikover.net\/yeni\/?page_id=8053"},"modified":"2025-11-25T01:23:35","modified_gmt":"2025-11-25T01:23:35","slug":"polikistik-over-sendromu-tedavisinde-akupunktur","status":"publish","type":"page","link":"https:\/\/polikistikover.net\/yeni\/polikistik-over-sendromu-tedavisinde-akupunktur\/","title":{"rendered":"Polikistik Over Sendromu Tedavisinde Akupunktur"},"content":{"rendered":"\n

En \u00e7ok a\u011fr\u0131 \u015fikayeti (migren, bel a\u011fr\u0131s\u0131) i\u00e7in tercih edilen geleneksel \u00c7in t\u0131bb\u0131n\u0131n (Traditional Chinese Medicine) bir par\u00e7as\u0131 olan akupunktur kullan\u0131m\u0131 gittik\u00e7e yayg\u0131nla\u015fmaktad\u0131r (1,2,3,4,30,31). <\/mark><\/strong><\/p>\n\n\n\n

Akupunktur son zamanlarda polikistik over sendromu tedavisinde de kullan\u0131lmaya ba\u015flanm\u0131\u015ft\u0131r.<\/mark><\/strong><\/p>\n\n\n\n

Akupunktur v\u00fccudun \u00e7e\u015fitli b\u00f6lgelerinde bulunan kaslarda veya kulak \u00fczerinde belirli akupunktur noktalar\u0131na i\u011fne bat\u0131r\u0131larak yap\u0131lan bir tedavi y\u00f6ntemidir.<\/p>\n\n\n\n

\u0130\u011fne bat\u0131r\u0131ld\u0131ktan sonra sinir sisteminin uyar\u0131lmas\u0131 belirli bir s\u00fcre elle (manual) ya da elektrik ak\u0131m\u0131 (electrostimulation) kullan\u0131larak yap\u0131lmaktad\u0131r(5,6,7).<\/p>\n\n\n\n

\u0130\u011fne bat\u0131r\u0131lan akupunktur noktalar\u0131nda uyar\u0131lan sinirler (peripheral nerves) omurilik ve beyinde bulunan baz\u0131 sinir h\u00fccrelerini (neurons) etkin (aktif) hale getirmektedir(5,6,7).<\/p>\n\n\n\n

SAKINCALARI;<\/strong><\/p>\n\n\n\n

1-<\/mark>Akupunktur uygulamas\u0131n\u0131n ba\u015far\u0131s\u0131n\u0131 di\u011fer tedavi y\u00f6ntemleriyle k\u0131yaslayan g\u00fcvenilir kar\u015f\u0131la\u015ft\u0131rmal\u0131  bilimsel \u00e7al\u0131\u015fmalar\u0131n (Randomised Controlled Trials) yetersiz say\u0131da olmas\u0131,<\/strong><\/p>\n\n\n\n

2-<\/mark>Kullan\u0131lan akupunktur noktalar\u0131n\u0131n yerleri, akupunktur uygulamas\u0131n\u0131n s\u00fcresi ve uygulama s\u0131kl\u0131\u011f\u0131 gibi konularda ortak bir fikir birli\u011finin olmamas\u0131,<\/strong><\/p>\n\n\n\n

3-<\/mark>Belirlenmi\u015f akupunktur noktalar\u0131 ile rastgele se\u00e7ilen yerlere yap\u0131lan i\u011fne uygulamalar\u0131 (Sham acupuncture) aras\u0131nda sonu\u00e7lar a\u00e7\u0131s\u0131ndan fazla bir fark olmamas\u0131,<\/strong><\/p>\n\n\n\n

4-<\/mark>Etkisinin ne kadar s\u00fcre devam etti\u011finin bilinmemesi,<\/strong><\/p>\n\n\n\n

5-<\/mark>\u00c7o\u011funlu\u011fu \u00c7in kaynakl\u0131 olan \u00e7al\u0131\u015fmalarda \u00e7o\u011funlukla akupunktur uygulamas\u0131 ile birlikte bitkisel tedavi (Herbal Medicine) y\u00f6ntemlerinin de uygulanm\u0131\u015f olmas\u0131,<\/strong><\/p>\n\n\n\n

6-<\/mark>Etki mekanizmas\u0131n\u0131n hen\u00fcz tam olarak ortaya konulmam\u0131\u015f olmas\u0131,<\/strong><\/p>\n\n\n\n

Akupunktur y\u00f6nteminin tek ba\u015f\u0131na ba\u015far\u0131s\u0131n\u0131 <\/strong>anlamam\u0131z\u0131 zorla\u015ft\u0131rmaktad\u0131r.<\/strong><\/p>\n\n\n\n

Etki Mekanizmas\u0131;<\/strong><\/p>\n\n\n\n

1-<\/mark><\/strong>Beyinde hipotalamus b\u00f6lgesinde GnRH (Gonadotropin-releasing hormone) salg\u0131layan sinir h\u00fccreleri (neurons) bulunmaktad\u0131r(10,11).<\/p>\n\n\n\n

2-<\/mark><\/strong>GnRH hormonunun belirli aral\u0131klarla art\u0131\u015flar ve azal\u0131\u015flar g\u00f6sterek (pulsatile) salg\u0131lanmas\u0131na ba\u011fl\u0131 olarak hipofiz bezinde LH ve FSH hormonlar\u0131n \u00fcretim s\u0131kl\u0131\u011f\u0131 (frequency) ve miktarlar\u0131 (amplitude) belirlenmektedir(10,11).<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

3-<\/mark><\/strong>Polikistik over sendromu olan kad\u0131nlar\u0131n bir k\u0131sm\u0131nda GnRH hormonu salg\u0131layan sinir h\u00fccrelerinden olu\u015fan jenerat\u00f6r (dinamo) fazla \u00e7al\u0131\u015fmaktad\u0131r (hyperactive)(10,11,12).<\/p>\n\n\n\n

4-<\/mark><\/strong>GnRH hormonunun salg\u0131lanma s\u0131kl\u0131\u011f\u0131n\u0131n artmas\u0131 hipofiz bezinde \u00fcretilen LH hormonunun salg\u0131lanma s\u0131kl\u0131\u011f\u0131n\u0131n (frequency) ve kan dola\u015f\u0131m\u0131nda bulunan miktar\u0131n\u0131n artmas\u0131na neden olmaktad\u0131r(10,12,13,14,15,16,17,18,19). <\/p>\n\n\n\n

5-<\/mark><\/strong>LH (luteinizing hormon) miktar\u0131n\u0131n artmas\u0131 erkeklik hormonlar\u0131n\u0131n yumurtal\u0131kta yap\u0131m\u0131n\u0131 artt\u0131rmakta (hiperandrogenism) ve yumurtlama \u00f6ncesi olgun folik\u00fcl (dominant) geli\u015fimini ve yumurtlamay\u0131 (ovulasyon) engellemektedir(12,19,20,21,22,23,24,25,26,27,28,29).<\/p>\n\n\n\n

6-<\/mark><\/strong>Beyinde belirli b\u00f6lgelerde pro-opiomelanocortine (POMC) den \u00fcretilen \u00df- endorfin (opioid) hipotalamus b\u00f6lgesinde bulunan GnRH (Gonadotropin-releasing hormone) salg\u0131layan jenerat\u00f6r\u00fcn (dinamo) \u00e7al\u0131\u015fmas\u0131n\u0131 bask\u0131lamaktad\u0131r (inhibition)(8,9,32,33,34,35,36,39,40).<\/p>\n\n\n\n

7-<\/mark><\/strong>Polikistik over sendromu olan kad\u0131nlar\u0131n bir k\u0131sm\u0131nda akupunktur uygulamas\u0131 sonras\u0131nda \u00df- endorfin miktar\u0131n\u0131n hipotalamus ve hipofiz bezinde artmas\u0131 nedeniyle hipotalamus\u2019tan fazla miktarda salg\u0131lanan GnRH (Gonadotropin-releasing hormone) ve hipofiz\u2019den fazla miktarda salg\u0131lanan LH (Luteinizing hormon) miktarlar\u0131 azalmaktad\u0131r(32,33,34,35,41).<\/p>\n\n\n\n

8-<\/mark><\/strong>Bunun sonucunda polikistik over sendromu olan kad\u0131nlar\u0131n bir k\u0131sm\u0131nda akupunktur uygulamas\u0131n\u0131 takiben yumurtlama \u00f6ncesi olgun folik\u00fcl (dominant) geli\u015fimi ve yumurtlama (ovulasyon) oldu\u011fu i\u00e7in adet kanamalar\u0131 daha d\u00fczenli (Eumenorrhea) olmaktad\u0131r(32,33,34,35,37,38,41).<\/p>\n\n\n\n

Polikistik over sendromu olan kad\u0131nlarda \u00e7ocuk iste\u011fi ve adet d\u00fczensizli\u011fi tedavisinde ancak di\u011fer tedavi y\u00f6ntemleriyle birlikte kullan\u0131ld\u0131\u011f\u0131 taktirde bir miktar fayda sa\u011flayabilir.\u00a0<\/mark><\/strong><\/p>\n\n\n\n

Akupunktur y\u00f6nteminin polikistik over sendromu tedavisinde tek ba\u015f\u0131na kullan\u0131lmas\u0131 do\u011fru de\u011fildir.<\/mark><\/strong><\/p>\n\n\n\n

 Kaynaklar<\/strong><\/p>\n\n\n\n

1-Acupuncture\u2013from empiricism to science: functional background to acupuncture effects in pain and disease. Andersson S, Lundeberg T. Med Hypotheses. 1995 Sep;45(3):271-81.<\/p>\n\n\n\n

2-Acupuncture in practice: mapping the providers, the patients and the settings in a national cross-sectional survey. Hopton AK, Curnoe S, Kanaan M, Macpherson H. BMJ Open. 2012 Jan 11;2(1):e000456.<\/p>\n\n\n\n

3-Prevalence of complementary and alternative medicine (CAM) use by the general population: a systematic review and update. Harris PE, Cooper KL, Relton C, Thomas KJ. Int J Clin Pract.  2012 Oct;66(10):924-39.<\/p>\n\n\n\n

4-Complementary and alternative medicine use in Australia: a national population-based survey. Xue CC, Zhang AL, Lin V, Da Costa C, Story DF. J Altern Complement Med. 2007 Jul-Aug;13(6):643-50.<\/p>\n\n\n\n

5-Acupuncture Points and Their Relationship with Multireceptive Fields of Neurons. Quiroz-Gonz\u00e1lez S, Torres- Castillo  S, L\u00f3pez-G\u00f3mez RE, Jim\u00e9nez Estrada I. J Acupunct Meridian Stud. 2017 Apr;10(2):81-89.<\/p>\n\n\n\n

6-Acupuncture modulates the neuro-endocrine-immune network. Ding SS, Hong SH, Wang C, Guo Y, Wang ZK, Xu Y. QJM. 2014 May;107(5):341-5.<\/p>\n\n\n\n

7-A New Perspective of Acupuncture: The Interaction among Three Networks Leads to Neutralization. Li NC, Li MY, Chen B, Guo Y. Evid Based Complement Alternat Med. 2019  Feb 24;2019:2326867.<\/p>\n\n\n\n

8-\u2013Pituitary stalk portal blood collection in rhesus monkeys: evidence for pulsatile release of gonadotropin-releasing hormone (GnRH). Carmel PW, Araki S, Ferin M. Endocrinology. 1976 Jul;99(1):243-8.<\/p>\n\n\n\n

9-Frequency and amplitude of gonadotropin-releasing hormone stimulation and gonadotropin secretion in the rhesus monkey. Wildt L, H\u00e4usler A, Marshall G, Hutchison JS, Plant TM, Belchetz PE, Knobil E. Endocrinology. 1981  Aug;109(2):376-85.<\/p>\n\n\n\n

10-GnRH pulse frequency-dependent differential regulation of LH and FSH gene expression. Thompson IR, Kaiser UB. Mol Cell Endocrinol. 2014 Mar 25;385(1-2):28-35.<\/p>\n\n\n\n

11-The frequency of gonadotropin-releasing-hormone stimulation differentially regulates gonadotropin subunit messenger ribonucleic acid expression. Dalkin AC, Haisenleder DJ, Ortolano GA, Ellis TR, Marshall JC. Endocrinology. 1989 Aug;125(2):917-24.<\/p>\n\n\n\n

12-The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome. Blank SK, McCartney CR, Marshall JC. Hum Reprod Update. 2006 Jul-Aug;12(4):351-61.<\/p>\n\n\n\n

13-Circulating luteinizing hormone pulse frequency in women with polycystic ovary syndrome. Kazer RR, Kessel B, Yen SS. J Clin Endocrinol Metab. 1987 Aug;65(2):233-6.<\/p>\n\n\n\n

14-Opioidergic regulation of LH pulsatility in women with polycystic ovary syndrome. Berga SL, Yen SS. Clin Endocrinol (Oxf). 1989 Feb;30(2):177-84.<\/p>\n\n\n\n

15-Inappropriate secretion of follicle-stimulating hormone and luteinizing hormone in polycystic ovarian disease. Yen SS, Vela P, Rankin J. J Clin Endocrinol Metab. 1970 Apr;30(4):435-42.<\/p>\n\n\n\n

16-Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome. Taylor AE, McCourt B, Martin KA, Anderson EJ, Adams JM, Schoenfeld D, Hall JE. J Clin Endocrinol Metab. 1997 Jul;82(7):2248-56.<\/p>\n\n\n\n

17-Hyperfunction of the hypothalamic-pituitary axis in women with polycystic ovarian disease: indirect evidence for partial gonadotroph desensitization. Waldstreicher J, Santoro NF, Hall JE, Filicori M, Crowley WF Jr. J Clin Endocrinol Metab. 1988 Jan;66(1):165-72.<\/p>\n\n\n\n

18-Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, Karaderi T, Barber TM, McCarthy MI, Franks S,Lindgren CM, Welt CK, Diamanti-Kandarakis E, Panidis D, Goodarzi MO, Azziz R, Zhang Y, James RG, Olivier M,Kissebah AH; Reproductive Medicine Network, Stener-Victorin E, Legro RS, Dunaif A. Nat Commun. 2015 Aug 18;6:7502.<\/p>\n\n\n\n

19-Metabolic regulation of androgen production by human thecal cells in vitro. Nahum R, Thong KJ, Hillier SG. Hum Reprod. 1995 Jan;10(1):75-81.<\/p>\n\n\n\n

20-Estradiol production by granulosa cells of normal and polycystic ovaries: relationship to menstrual cycle history and concentrations of gonadotropins and sex steroids in follicular fluid. Mason HD, Willis DS, Beard RW, Winston RM, Margara R, Franks S. J Clin Endocrinol Metab. 1994 Nov;79(5):1355-60.<\/p>\n\n\n\n

21-Premature response to luteinizing hormone of granulosa cells from anovulatory women with polycystic ovary syndrome: relevance to mechanism of anovulation. Willis DS, Watson H, Mason HD, Galea R, Brincat M, Franks S. J Clin Endocrinol Metab. 1998 Nov;83(11):3984-91.<\/p>\n\n\n\n

22-Etiology of anovulation in polycystic ovary syndrome. Franks S, Mason H, White D, Willis D. Steroids. 1998 May-Jun;63(5-6):306-7.<\/p>\n\n\n\n

23-Follicle dynamics and anovulation in polycystic ovary syndrome. Franks S, Stark J, Hardy K. Hum Reprod Update. 2008 Jul-Aug;14(4):367-78.<\/p>\n\n\n\n

24-Increased protein expression of LHCG receptor and 17\u03b1-hydroxylase\/17-20-lyase in human polycystic ovaries. Comim FV, Teerds K, Hardy K, Franks S. Hum Reprod. 2013 Nov;28(11):3086-92.<\/p>\n\n\n\n

25-Developmental programming: rescuing disruptions in preovulatory follicle growth and steroidogenesis from prenatal testosterone disruption. Veiga-Lopez A, Moeller J, Abbott DH, Padmanabhan V. J Ovarian Res. 2016 Jun 29;9(1):39.<\/p>\n\n\n\n

26-Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome. Cadagan D, Khan R, Amer S. Reprod Biol. 2016 Mar;16(1):53-60.<\/p>\n\n\n\n

27-Current concepts of the roles of follicle stimulating hormone and luteinizing hormone in folliculogenesis. Hillier SG. Hum Reprod. 1994 Feb;9(2):188-91.<\/p>\n\n\n\n

28-Cellular aspects of pre-ovulatory folliculogenesis in primate ovaries. Hillier SG, Harlow CR, Shaw HJ, Wickings EJ, Dixson AF, Hodges JK. Hum Reprod. 1988 May;3(4):507-11.<\/p>\n\n\n\n

29-Intrafollicular paracrine function of ovarian androgen. Hillier SG. J Steroid Biochem. 1987;27(1-3):351-7.<\/p>\n\n\n\n

30-Meta-analysis: acupuncture for low back pain. Manheimer E, White A, Berman B, Forys K, Ernst E. Ann Intern Med. 2005 Apr 19;142(8):651-63.<\/p>\n\n\n\n

31-Acupuncture for the prevention of tension-type headache. Linde K, Allais G, Brinkhaus B, Fei Y, Mehring M, Shin BC, Vickers A, White AR. Cochrane Database Syst Rev.2016 Apr 19;4:CD007587.<\/p>\n\n\n\n

32-Close anatomical associations between beta-endorphin and luteinizing hormone-releasing hormone neuronal systems in the human diencephalon. Dud\u00e1s B, Merhenthaler I. Neuroscience. 2004;124(1):221-9.<\/p>\n\n\n\n

33-The influence of acupuncture stimulation on plasma levels of LH, FSH, progesterone and estradiol in normally ovulating women. Aso T, Motohashi T, Murata M, Nishimura T, Kakizaki K. Am J Chin Med (Gard City N Y). 1976 WINTER;4(4):391-401.<\/p>\n\n\n\n

34-Acupuncture normalizes dysfunction of hypothalamic-pituitary-ovarian axis. Chen BY. Acupunct Electrother Res. 1997;22(2):97-108.<\/p>\n\n\n\n

35-Relationship between blood radioimmunoreactive beta-endorphin and hand skin temperature during the electro-acupuncture induction of ovulation. Chen BY, Yu J. Acupunct Electrother Res. 1991;16(1-2):1-5.<\/p>\n\n\n\n

36-70 years of opioid research: the exciting but vain quest for the Holy Grail. orrbett AD, Henderson G, McKnight AT, Paterson SJ. Br J Pharmacol.  2006 Jan;147 Suppl 1:S153-62.<\/p>\n\n\n\n

37-Effects of electro-acupuncture on anovulation in women with polycystic ovary syndrome. Stener-Victorin E, Waldenstr\u00f6m U, T\u00e4gnfors U, Lundeberg T, Lindstedt G, Janson PO. Acta Obstet Gynecol Scand. 2000 Mar;79(3):180-8.<\/p>\n\n\n\n

38-Acupuncture for polycystic ovarian syndrome. Lim CED, Ng RWC, Cheng NCL, Zhang GS, Chen H. Cochrane Database Syst Rev. 2019 Jul 2;7:CD007689.<\/p>\n\n\n\n

39-Neuroendocrine Impairments of Polycystic Ovary Syndrome.Ruddenklau A, Campbell RE. Endocrinology. 2019 Oct 1;160(10):2230-2242.<\/p>\n\n\n\n

40-New Perspectives on the Pathogenesis of PCOS: Neuroendocrine Origins. Walters KA, Gilchrist RB, Ledger WL, Teede HJ, Handelsman DJ, Campbell RE. Trends Endocrinol Metab. 2018 Dec;29(12):841-852.<\/p>\n\n\n\n

41-Acupuncture for polycystic ovarian syndrome: A systematic review and meta-analysis. Jo J, Lee YJ, Lee H. Medicine (Baltimore). 2017 Jun;96(23):e7066.<\/p>\n","protected":false},"excerpt":{"rendered":"

En \u00e7ok a\u011fr\u0131 \u015fikayeti (migren, bel a\u011fr\u0131s\u0131) i\u00e7in tercih edilen geleneksel \u00c7in t\u0131bb\u0131n\u0131n (Traditional Chinese Medicine) bir par\u00e7as\u0131 olan akupunktur kullan\u0131m\u0131 gittik\u00e7e yayg\u0131nla\u015fmaktad\u0131r (1,2,3,4,30,31).  Akupunktur son zamanlarda polikistik over sendromu tedavisinde de kullan\u0131lmaya ba\u015flanm\u0131\u015ft\u0131r. Akupunktur v\u00fccudun \u00e7e\u015fitli b\u00f6lgelerinde bulunan kaslarda veya kulak \u00fczerinde belirli akupunktur noktalar\u0131na i\u011fne bat\u0131r\u0131larak yap\u0131lan bir tedavi y\u00f6ntemidir. \u0130\u011fne bat\u0131r\u0131ld\u0131ktan sonra sinir […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8053","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8053","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/comments?post=8053"}],"version-history":[{"count":12,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8053\/revisions"}],"predecessor-version":[{"id":11284,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8053\/revisions\/11284"}],"wp:attachment":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/media?parent=8053"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}