{"id":8105,"date":"2025-09-28T02:33:11","date_gmt":"2025-09-28T02:33:11","guid":{"rendered":"https:\/\/polikistikover.net\/yeni\/?page_id=8105"},"modified":"2025-11-21T02:18:17","modified_gmt":"2025-11-21T02:18:17","slug":"40-yasindan-sonra-polikistik-over-sendromu","status":"publish","type":"page","link":"https:\/\/polikistikover.net\/yeni\/40-yasindan-sonra-polikistik-over-sendromu\/","title":{"rendered":"40 Ya\u015f\u0131ndan Sonra Polikistik Over Sendromu"},"content":{"rendered":"\n

Ergenlik d\u00f6neminden itibaren yumurta geli\u015fiminin yava\u015f olmas\u0131\u00a0(oligoovulasyon)\u00a0veya olmamas\u0131\u00a0(anovulasyon)\u00a0nedeniyle adet kanamas\u0131 geciken veya olmayan polikistik over sendromu olan kad\u0131nlar\u0131n b\u00fcy\u00fck bir k\u0131sm\u0131 fazla miktarda olan erkeklik hormonlar\u0131n\u0131n miktar\u0131n\u0131n ve yumurta (antral folik\u00fcl) say\u0131s\u0131n\u0131n azalmas\u0131na\u00a0ba\u011fl\u0131 olarak ya\u015f ilerledik\u00e7e daha d\u00fczenli adet g\u00f6rmeye ba\u015flamakta ve hatta 30 lu ya\u015flar\u0131n ortalar\u0131ndan itibaren daha kolay gebe kalabilmektedirler(1,2,3,4,5).<\/mark><\/strong><\/p>\n\n\n\n

1-<\/mark><\/strong>Polikistik over sendromu olsun ya da olmas\u0131n b\u00fct\u00fcn kad\u0131nlarda erkeklik hormonlar\u0131n\u0131n miktarlar\u0131 ya\u015f ilerledik\u00e7e 20 li ya\u015flardan itibaren \u00f6zellikle 40 l\u0131 ya\u015flar\u0131 takiben azalmaktad\u0131r(14). Bu azalma kad\u0131n menopoza girmi\u015f olsa da olmasa da g\u00f6r\u00fclmektedir(6,7,8,9,10).<\/p>\n\n\n\n

2-<\/mark><\/strong>Menopoz sonras\u0131 d\u00f6nemde de erkeklik hormonlar\u0131 yumurtal\u0131k, b\u00f6brek \u00fcst\u00fc bezi ve ya\u011f dokusunda \u00fcretilmeye devam etmektedir(12,13). Menopoz sonras\u0131 (postmenopoz) d\u00f6nemde \u00f6strojen (Estradiol) hormonu miktar\u0131 azalmaktad\u0131r(11). <\/p>\n\n\n\n

3-<\/mark><\/strong>\u00d6strojen (E2) hormonu miktar\u0131n\u0131n azalmas\u0131 erkeklik hormonlar\u0131n\u0131 ba\u011flayan SHBG (Sex Hormon Binding Globulin) miktar\u0131n\u0131n azalmas\u0131na neden olmaktad\u0131r(9,11).<\/p>\n\n\n\n

4-<\/mark><\/strong>Sonu\u00e7 olarak menopoz sonras\u0131 d\u00f6nemde SHBG miktar\u0131n\u0131n azalmas\u0131 serbest dola\u015fan erkeklik hormonlar\u0131n\u0131 (serbest testosteron) artt\u0131rmaktad\u0131r(9,11).<\/p>\n\n\n\n

Ya\u015f ilerledik\u00e7e erkeklik hormonlar\u0131n\u0131n (testosteron, androstenedion, DHEA-S ) ve bunlar\u0131n etkin formu olan Dihidrotestosteron (DHT) \u00fcretimi polikistik over sendromu olan kad\u0131nlarda da di\u011fer kad\u0131nlarda oldu\u011fu gibi azalmaktad\u0131r(3,4,5,15,16,17,18). <\/p>\n\n\n\n

5-<\/mark><\/strong>Polikistik over sendromu\u2019nda erkeklik hormonlar\u0131 polikistik over sendromu olmayan kad\u0131nlara g\u00f6re azalsa bile normalden daha fazla miktarlarda olmaya devam etmektedir(3,4,5,15,16,17,18).<\/p>\n\n\n\n

Hatta 50 li ya\u015flar\u0131 takiben erkeklik hormonlar\u0131n\u0131n etkinli\u011fi erkeklik hormonlar\u0131n\u0131 ba\u011flayan SHBG (Sex Hormon Binding Globulin) miktar\u0131n\u0131n azalmas\u0131 nedeniyle biraz daha artmaktad\u0131r(15,18,19,20). Bu durum polikistik over sendromu olan kad\u0131nlarda t\u00fcylenme art\u0131\u015f\u0131, sivilce, ciltte ya\u011flanma ve erkek tipi sa\u00e7 d\u00f6k\u00fclmesi \u015fikayetlerinin ileri ya\u015flarda da menopoz sonras\u0131 d\u00f6nemde devam etmesine neden olmaktad\u0131r.<\/mark><\/strong><\/p>\n\n\n\n

Kaynaklar<\/strong><\/p>\n\n\n\n

1-Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long-term follow-up focusing on natural history and circulating hormones. Dahlgren E, Johansson S, Lindstedt G, Knutsson F, Od\u00e9n A, Janson PO, Mattson LA, Crona N, Lundberg PA. Fertil Steril. 1992 Mar;57(3):505-13.<\/p>\n\n\n\n

2-Women with polycystic ovary syndrome gain regular menstrual cycles when ageing. Elting MW, Korsen TJ, Rekers-Mombarg LT, Schoemaker J. Hum Reprod. 2000 Jan;15(1):24-8.<\/p>\n\n\n\n

3-Serum testosterone levels decrease in middle age in women with the polycystic ovary syndrome. Winters SJ, Talbott E, Guzick DS, Zborowski J, McHugh KP. Fertil Steril. 2000 Apr;73(4):724-9.<\/p>\n\n\n\n

4-Age-related differences in features associated with polycystic ovary syndrome in normogonadotrophic oligo-amenorrhoeic infertile women of reproductive years. Bili H, Laven J, Imani B, Eijkemans MJ, Fauser BC. Eur J Endocrinol. 2001 Dec;145(6):749-55.<\/p>\n\n\n\n

5-Long-term follow-up of patients with polycystic ovary syndrome: reproductive outcome and ovarian reserve. Hudecova M, Holte J, Olovsson M, Sundstr\u00f6m Poromaa I. Hum Reprod. 2009 May;24(5):1176-83.<\/p>\n\n\n\n

6-Steroid hormones and aging: free testosterone, testosterone and androstenedione in normal females aged 20-87 years. Purifoy FE, Koopmans LH, Tatum RW. Hum Biol. 1980 May;52(2):181-91.<\/p>\n\n\n\n

7-Twenty-four-hour mean plasma testosterone concentration declines with age in normal premenopausal women. Zumoff B, Strain GW, Miller LK, Rosner W. J Clin Endocrinol Metab. 1995 Apr;80(4):1429-30.<\/p>\n\n\n\n

8-The relationship of circulating dehydroepiandrosterone, testosterone, and estradiol to stages of the menopausal transition and ethnicity. Lasley BL, Santoro N, Randolf JF, Gold EB, Crawford S, Weiss G, McConnell DS, Sowers MF. J Clin Endocrinol Metab. 2002 Aug;87(8):3760-7.<\/p>\n\n\n\n

9-A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition. Burger HG, Dudley EC, Cui J, Dennerstein L, Hopper JL. J Clin Endocrinol Metab. 2000 Aug;85(8):2832-8.<\/p>\n\n\n\n

10-Testosterone therapy in women: a review. Bolour S, Braunstein G.bInt J Impot Res. 2005 Sep-Oct;17(5):399-408.<\/p>\n\n\n\n

11-The endocrinology of the menopause. Burger HG. Maturitas. 1996 Mar;23(2):129-36.<\/p>\n\n\n\n

12-The hormonal activity of the postmenopausal ovary. Vermeulen A. J Clin Endocrinol Metab. 1976 Feb;42(2):247-53.<\/p>\n\n\n\n

13-Effect of oophorectomy on circulating testosterone and androstenedione levels in patients with endometrial cancer. Judd HL, Lucas WE, Yen SS. Am J Obstet Gynecol. 1974 Mar 15;118(6):793-8.<\/p>\n\n\n\n

14-Androgen levels in adult females: changes with age, menopause, and oophorectomy. Davison SL , Bell R, Donath S, Montalto JG, Davis SR. J Clin Endocrinol Metab. 2005 Jul;90(7):3847-53.<\/p>\n\n\n\n

15-Hyperandrogenism in women with polycystic ovary syndrome persists after menopause. Markopoulos MC, Rizos D, Valsamakis G, Deligeoroglou E, Grigoriou O, Chrousos GP, Creatsas G, Mastorakos G. J Clin Endocrinol Metab. 2011 Mar;96(3):623-31.<\/p>\n\n\n\n

16-Clinical and biochemical presentation of polycystic ovary syndrome in women between the ages of 20 and 40. Liang SJ, Hsu CS, Tzeng CR, Chen CH, Hsu MI. Hum Reprod. 2011 Dec;26(12):3443-9.<\/p>\n\n\n\n

17-Ovarian age-related responsiveness to human chorionic gonadotropin in women with polycystic ovary syndrome. Piltonen T, Koivunen R, Perheentupa A, Morin-Papunen L, Ruokonen A, Tapanainen JS. J Clin Endocrinol Metab. 2004 Aug;89(8):3769-75.<\/p>\n\n\n\n

18-Unfavorable hormonal, metabolic, and inflammatory alterations persist after menopause in women with PCOS. Puurunen J, Piltonen T, Morin-Papunen L, Perheentupa A, J\u00e4rvel\u00e4 I, Ruokonen A, Tapanainen JS. J Clin Endocrinol Metab. 2011 Jun;96(6):1827-34.<\/p>\n\n\n\n

19-Androgen Profile Through Life in Women With Polycystic Ovary Syndrome: A Nordic Multicenter Collaboration Study. Pinola P, Piltonen TT, Puurunen J, Vanky E, Sundstr\u00f6m-Poromaa I, Stener-Victorin E, Ruokonen A, Puukka K, Tapanainen JS, Morin-Papunen LC.J Clin Endocrinol Metab. 2015 Sep;100(9):3400-7.<\/p>\n\n\n\n

20-Reproductive hormone levels and anthropometry in postmenopausal women with polycystic ovary syndrome (PCOS): a 21-year follow-up study of women diagnosed with PCOS around 50 years ago and their age-matched controls. Schmidt J, Br\u00e4nnstr\u00f6m M, Landin-Wilhelmsen K, Dahlgren E. J Clin Endocrinol Metab. 2011 Jul;96(7):2178-85.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ergenlik d\u00f6neminden itibaren yumurta geli\u015fiminin yava\u015f olmas\u0131\u00a0(oligoovulasyon)\u00a0veya olmamas\u0131\u00a0(anovulasyon)\u00a0nedeniyle adet kanamas\u0131 geciken veya olmayan polikistik over sendromu olan kad\u0131nlar\u0131n b\u00fcy\u00fck bir k\u0131sm\u0131 fazla miktarda olan erkeklik hormonlar\u0131n\u0131n miktar\u0131n\u0131n ve yumurta (antral folik\u00fcl) say\u0131s\u0131n\u0131n azalmas\u0131na\u00a0ba\u011fl\u0131 olarak ya\u015f ilerledik\u00e7e daha d\u00fczenli adet g\u00f6rmeye ba\u015flamakta ve hatta 30 lu ya\u015flar\u0131n ortalar\u0131ndan itibaren daha kolay gebe kalabilmektedirler(1,2,3,4,5). 1-Polikistik over sendromu […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8105","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/comments?post=8105"}],"version-history":[{"count":8,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8105\/revisions"}],"predecessor-version":[{"id":12898,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8105\/revisions\/12898"}],"wp:attachment":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/media?parent=8105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}