{"id":8202,"date":"2025-09-28T04:27:26","date_gmt":"2025-09-28T04:27:26","guid":{"rendered":"https:\/\/polikistikover.net\/yeni\/?page_id=8202"},"modified":"2025-11-22T01:41:06","modified_gmt":"2025-11-22T01:41:06","slug":"anti-mullerian-hormon-amh","status":"publish","type":"page","link":"https:\/\/polikistikover.net\/yeni\/anti-mullerian-hormon-amh\/","title":{"rendered":"Anti-Mullerian Hormon (AMH)"},"content":{"rendered":"\n

Yumurtal\u0131klarda yumurtalar\u0131 i\u00e7inde ta\u015f\u0131yan k\u00fc\u00e7\u00fck keseciklerin (preantral ve antral folik\u00fcller) duvar\u0131n\u0131 d\u00f6\u015feyen h\u00fccreler taraf\u0131ndan (granulosa h\u00fccreleri) Anti-M\u00fcllerian Hormon (AMH) \u00fcretilmektedir(1,2).<\/mark><\/strong><\/p>\n\n\n\n

AMH miktar\u0131 kad\u0131nlarda ya\u015f ilerledik\u00e7e yumurta say\u0131s\u0131n\u0131n yani k\u00fc\u00e7\u00fck keseciklerin (preantral ve antral folik\u00fcller) azalmas\u0131na paralel olarak azalmaktad\u0131r(3,4). <\/p>\n\n\n\n

Menopoz k\u00fc\u00e7\u00fck keseciklerin (preantral ve antral folik\u00fcller) t\u00fckenmesi anlam\u0131na gelmektedir.<\/p>\n\n\n\n

Menopoz veya erken menopoz \u00f6ncesinde AMH miktar\u0131 \u00e7ok \u00e7ok azalmaktad\u0131r.<\/p>\n\n\n\n

Anti-M\u00fcllerian Hormon miktar\u0131 ki\u015finin polikistik over sendromu\u2019nun hangi grubuna girdi\u011fini ve polikistik over sendromu\u2019nun \u015fiddetini g\u00f6stermektedir (15,16).<\/p>\n\n\n\n

Polikistik over sendromu olan kad\u0131nlarda kanda AMH miktar\u0131 polikistik over sendromu olmayan kad\u0131nlardan daha fazla miktarda bulunmaktad\u0131r (5). <\/p>\n\n\n\n

Polikistik over sendromu olan kad\u0131nlarda AMH miktar\u0131n\u0131n fazla olmas\u0131n\u0131n tek nedeni AMH nin \u00fcretildi\u011fi preantal ve antral folik\u00fcl say\u0131s\u0131n\u0131n fazla olmas\u0131 de\u011fildir (18).<\/mark><\/strong><\/p>\n\n\n\n

AMH miktar\u0131n\u0131n fazla olmas\u0131n\u0131n di\u011fer nedeni de polikistik over sendromu olan kad\u0131nlarda AMH \u00fcretimi yapan h\u00fccrelerin \u00fcretim kapasitesinin polikistik over sendromu olmayan kad\u0131nlar\u0131n AMH \u00fcreten h\u00fccrelerinin kapasitesinden \u00e7ok daha fazla olmas\u0131d\u0131r (6).<\/mark><\/strong><\/p>\n\n\n\n

Yumurtal\u0131kta erkeklik hormonlar\u0131 AMH hormonu \u00fcreten granulosa h\u00fccrelerinin d\u0131\u015f k\u0131sm\u0131n\u0131 d\u00f6\u015feyen h\u00fccrelerde (teka h\u00fccreleri) ve yumurtal\u0131\u011f\u0131n \u00e7evresine dizilmi\u015f k\u00fc\u00e7\u00fck keseciklerin ortas\u0131nda bulunan b\u00f6lgede (stroma) \u00fcretilmektedir(10).<\/p>\n\n\n\n

AMH miktar\u0131 erkeklik hormonlar\u0131n\u0131n (testosteron gibi) miktar\u0131 ile do\u011fru orant\u0131l\u0131 olarak de\u011fi\u015fmektedir. <\/p>\n\n\n\n

Bu nedenle erkeklik hormonlar\u0131n\u0131n fazla miktarda \u00fcretildi\u011fi t\u00fcylenme art\u0131\u015f\u0131, erkek tipi sa\u00e7 d\u00f6k\u00fclmesi ve sivilce \u015fikayetlerinin g\u00f6r\u00fcld\u00fc\u011f\u00fc polikistik over sendromu\u2019nun alt gruplar\u0131ndan A ve B grubuna giren kad\u0131nlarda AMH daha fazla miktarda bulunmaktad\u0131r(7,8,9).<\/p>\n\n\n\n

Polikistik over sendromu olan kad\u0131nlar\u0131n bir k\u0131sm\u0131nda ins\u00fclin direncine ba\u011fl\u0131 olarak ins\u00fclin hormonu fazla miktarda \u00fcretilmektedir(11,12). <\/p>\n\n\n\n

Fazla miktarda \u00fcretilen ins\u00fclin hormonu yumurtal\u0131kta teka h\u00fccrelerinde ve stromada erkeklik hormonu \u00fcretimini artt\u0131rmaktad\u0131r (13). <\/p>\n\n\n\n

Erkeklik hormonlar\u0131nda olu\u015fan art\u0131\u015fa paralel olarak bu ki\u015filerde AMH miktar\u0131 da fazla bulunmaktad\u0131r. <\/p>\n\n\n\n

Buna kar\u015f\u0131l\u0131k ins\u00fclin direncinin ve buna ba\u011fl\u0131 olarak ins\u00fclin hormonu miktar\u0131n\u0131n tedavi ile azalmas\u0131 AMH hormonu miktar\u0131n\u0131 azaltmaktad\u0131r (14).<\/p>\n\n\n\n

Polikistik over sendromu ve adet d\u00fczensizli\u011fi olan kad\u0131nlarda kan dola\u015f\u0131m\u0131nda AMH miktar\u0131 d\u00fczenli adet g\u00f6ren polikistik over sendromu olan kad\u0131nlardan daha fazla miktarda bulunmaktad\u0131r.<\/p>\n\n\n\n

AMH miktar\u0131na g\u00f6re polikistik over sendromu olan kad\u0131nlar\u0131 yumurta geli\u015fimi ve yumurtlama a\u00e7\u0131s\u0131ndan iki gruba ay\u0131rabiliriz (6);<\/mark><\/strong><\/p>\n\n\n\n

1-<\/mark> AMH miktar\u0131 fazla olan,\u00a0adet d\u00fczensizli\u011fi\u00a0ve\u00a0gebe kalmakta zorluk\u00a0ya\u015fayanlar<\/mark><\/strong><\/p>\n\n\n\n

2-<\/mark> <\/mark>AMH miktar\u0131 fazla olmayan, d\u00fczenli adet olan ve gebe kalmakta zorluk ya\u015famayanlar<\/mark><\/strong><\/p>\n\n\n\n

Yukar\u0131da belirtilen ikinci gruba giren yani ba\u015flang\u0131\u00e7ta AMH miktar\u0131 fazla olmayan ve polikistik over sendromu olan kad\u0131nlarda kilo verilmesi ve v\u00fccut ya\u011f oran\u0131n\u0131n azalt\u0131lmas\u0131 yumurta geli\u015fimine ve yumurtlamaya neden olarak adetlerin d\u00fczene girmesini ve bunun sonucunda gebe kal\u0131nmas\u0131n\u0131 sa\u011flamaktad\u0131r (17).<\/mark><\/strong><\/p>\n\n\n\n

Fakat, AMH miktar\u0131 ba\u015flang\u0131\u00e7ta fazla olan birinci gruba giren kad\u0131nlarda ise kilo verilmesi ve v\u00fccut ya\u011f oran\u0131n\u0131n azalt\u0131lmas\u0131 tedavide daha az etkili olmaktad\u0131r. <\/mark><\/strong><\/p>\n\n\n\n

Adet d\u00fczensizli\u011fi ve \u00e7ocuk iste\u011fi tedavilerinde birinci gruba giren kad\u0131nlarda AMH miktar\u0131n\u0131n azalt\u0131lmas\u0131 polikistik over sendromu tedavisinde ba\u015far\u0131ya etki eden \u00f6nemli bir fakt\u00f6rd\u00fcr.<\/mark><\/strong><\/p>\n\n\n\n

Kaynaklar<\/strong><\/p>\n\n\n\n

1-Expression of anti-M\u00fcllerian hormone during normal and pathological gonadal development: association with differentiation of Sertoli and granulosa cells. Rajpert- de Meyts E, J\u00f8rgensen N, Graem N, M\u00fcller J, Cate RL, Skakkebaek NE. J Clin Endocrinol Metab. 1999 Oct;84(10):3836-44.<\/p>\n\n\n\n

2-Anti-M\u00fcllerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Weenen C, Laven JS, Von Bergh AR, Cranfield M, Groome NP, Visser JA, Kramer P, Fauser BC, Themmen AP. Mol Hum Reprod. 2004 Feb;10(2):77-83.<\/p>\n\n\n\n

3- Serum anti -mullerian hormone levels: a novel measure of ovarian reserve. Van Roji Broekmans FJ, te Velde ER, Fauser BC, Bancsi LF, de Jong FH, Themmen AP. Hum Reprod. 2002 Dec;17(12):3065-71.<\/p>\n\n\n\n

4-The variability of female reproductive ageing. V elde ER, Pearson PL. Hum Reprod Update. 2002 Mar-Apr;8(2):141-54.<\/p>\n\n\n\n

5-M\u00fcllerian-inhibiting substance in follicular fluid and serum: a comparison of patients with tubal factor infertility, polycystic ovary syndrome, and endometriosis. Fertil Steril. 1997 May;67(5):962-5.<\/p>\n\n\n\n

6-Granulosa cell production of anti-M\u00fcllerian hormone is increased in polycystic ovaries. Pellat L, Hanna L, Brincat M, Galea R, Brain H, Whitehead S, Mason H. J Clin Endocrinol Metab. 2007 Jan;92(1):240.<\/p>\n\n\n\n

7-Elevated serum level of anti-mullerian hormone in patients with polycystic ovary syndrome: relationship to the ovarian follicle excess and to the follicular arrest. Pigny P, Merlen E, Robert Y, Cortet-Rudelli C, Decanter C, Jonard S, Dewailly D. J Clin Endocrinol Metab. 2003 Dec;88(12):5957-62.<\/p>\n\n\n\n

8-Anti-M\u00fcllerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age. Laven JS, Mulders AG, Visser JA, Themmen AP, De Jong FH, Fauser BC. J Clin Endocrinol Metab. 2004Jan;89(1):318-23.<\/p>\n\n\n\n

9-Serum anti-Mullerian hormone levels during controlled ovarian hyperstimulation in women with polycystic ovaries with and without hyperandrogenism. Eldar Geva T, Margalioth EJ, Gal M, Ben-Chetrit A, Algur N, Zylber-Haran E, Brooks B, Huerta M, Spitz IM. Hum Reprod. 2005 Jul;20(7):1814.<\/p>\n\n\n\n

10-Insulin stimulates androgen accumulation in incubations of human ovarian stroma and theca. Barbieri RL, Makris A, Ryan KJ. Obstet Gynecol. 1984 Sep;64(3 Suppl):73S-80S.<\/p>\n\n\n\n

11-Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease. Burghen GA, Givens JR, Kitabchi AE. J Clin Endocrinol Metab. 1980 Jan;50(1):113-6.<\/p>\n\n\n\n

12-Clinical implications of hyperinsulinaemia in women. Conway GS , Jacobs HS. Clin Endocrinol (Oxf). 1993 Dec;39(6):623-32.<\/p>\n\n\n\n

13-Modulation by insulin of follicle-stimulating hormone and luteinizing hormone actions in human granulosa cells of normal and polycystic ovaries. Willis D, Mason H, Gilling-Smith C, Franks S. J Clin Endocrinol Metab. 1996 Jan;81(1):302-9.<\/p>\n\n\n\n

14- Metformin reduces serum mullerian-inhibiting substance levels in women with polycystic ovary syndrome after protracted treatment. Fleming R, Harborne L, MacLaughlin DT, Ling D, Norman J, Sattar N, Seifer DB. Fertil Steril. 2005 Jan;83(1):130-6.<\/p>\n\n\n\n

15-Anti-M\u00fcllerian hormone reflects the severity of polycystic ovary syndrome. Jacob JL, Field HP, Calder N, Picton HM, Balen AH, Barth JH. Clin Endocrinol (Oxf). 2017 Mar;86(3):395-400.The relationship of serum anti-Mullerian hormone with polycystic ovarian morphology and polycystic ovary syndrome: a prospective cohort study.<\/p>\n\n\n\n

16-The relationship of serum anti-Mullerian hormone with polycystic ovarian morphology and polycystic ovary syndrome: a prospective cohort study. Homburg R, Ray A, Bhide P, Gudi A, Shah A, Timms P, Grayson K. Hum Reprod. 2013  Apr;28(4):1077-83. 1.<\/p>\n\n\n\n

17-The use of anti-mullerian hormone in predicting menstrual response after weight loss in overweight women with polycystic ovary syndrome. Moran LJ, Noakes M, Clifton PM, Norman RJ. J Clin Endocrinol Metab. 2007 Oct;92(10):3796-802.<\/p>\n\n\n\n

18-Morphology and morphogenesis of the Stein-Leventhal ovary and of so-called \u201chyperthecosis\u201d Hughesdon PE. Obstet Gynecol Surv. 1982 Feb;37(2):59-77.<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Yumurtal\u0131klarda yumurtalar\u0131 i\u00e7inde ta\u015f\u0131yan k\u00fc\u00e7\u00fck keseciklerin (preantral ve antral folik\u00fcller) duvar\u0131n\u0131 d\u00f6\u015feyen h\u00fccreler taraf\u0131ndan (granulosa h\u00fccreleri) Anti-M\u00fcllerian Hormon (AMH) \u00fcretilmektedir(1,2). AMH miktar\u0131 kad\u0131nlarda ya\u015f ilerledik\u00e7e yumurta say\u0131s\u0131n\u0131n yani k\u00fc\u00e7\u00fck keseciklerin (preantral ve antral folik\u00fcller) azalmas\u0131na paralel olarak azalmaktad\u0131r(3,4). Menopoz k\u00fc\u00e7\u00fck keseciklerin (preantral ve antral folik\u00fcller) t\u00fckenmesi anlam\u0131na gelmektedir. Menopoz veya erken menopoz \u00f6ncesinde AMH miktar\u0131 \u00e7ok […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8202","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8202","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/comments?post=8202"}],"version-history":[{"count":15,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8202\/revisions"}],"predecessor-version":[{"id":12912,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8202\/revisions\/12912"}],"wp:attachment":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/media?parent=8202"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}