{"id":8353,"date":"2025-09-28T10:08:10","date_gmt":"2025-09-28T10:08:10","guid":{"rendered":"https:\/\/polikistikover.net\/yeni\/?page_id=8353"},"modified":"2025-11-04T07:49:27","modified_gmt":"2025-11-04T07:49:27","slug":"dogum-kontrol-hapi-kullanimi-ve-meme-kanseri","status":"publish","type":"page","link":"https:\/\/polikistikover.net\/yeni\/dogum-kontrol-hapi-kullanimi-ve-meme-kanseri\/","title":{"rendered":"Do\u011fum Kontrol Hap\u0131 Kullan\u0131m\u0131 ve Meme Kanseri"},"content":{"rendered":"\n

Meme kanseri kad\u0131nlarda en fazla kar\u015f\u0131la\u015f\u0131lan kanserdir.<\/mark><\/strong><\/p>\n\n\n\n

1-<\/mark><\/strong>Meme kanseri g\u00f6r\u00fclme ihtimalini (riskini) artt\u0131ran ve azaltan baz\u0131 \u00f6zellikler polikistik over sendromu olan kad\u0131nlar\u0131n bir k\u0131sm\u0131nda bulunmaktad\u0131r.<\/p>\n\n\n\n

2-<\/mark><\/strong>Meme kanseri \u00e7o\u011funlukla ileri ya\u015flarda menopoz sonras\u0131 d\u00f6nemde ortaya \u00e7\u0131kmaktad\u0131r.<\/p>\n\n\n\n

3-<\/mark><\/strong>Gen\u00e7 ya\u015flarda g\u00f6r\u00fclen meme kanseri \u00e7o\u011funlukla do\u011fum kontrol hap\u0131 kullan\u0131m\u0131 <\/a>ile birlikte genetik (ailesel) nedenlere ba\u011fl\u0131d\u0131r(1).<\/p>\n\n\n\n

4<\/strong>–<\/mark>\u0130leri <\/mark>ya\u015flarda, menopoz sonras\u0131 d\u00f6nemde,\u00a0ortaya \u00e7\u0131kan meme kanseri polikistik over sendromu ile daha \u00e7ok ili\u015fkilidir.<\/p>\n\n\n\n

5-<\/mark><\/strong>Do\u011fum kontrol hap\u0131 kullan\u0131m\u0131 meme kanseri ihtimalini art\u0131rmaktad\u0131r(2,4,6,7).<\/p>\n\n\n\n

6-<\/mark><\/strong>Do\u011fum kontrol haplar\u0131n\u0131n i\u00e7inde bulunan suni \u00f6strojen (ethinyl estradiol) miktar\u0131 ve suni progesteron \u00e7e\u015fidi bu ihtimali artt\u0131ran nedenlerdir(2,4,8).<\/p>\n\n\n\n

7-<\/mark><\/strong>Do\u011fum kontrol hap\u0131n\u0131n kullan\u0131m s\u00fcresi artt\u0131k\u00e7a meme kanseri ihtimali de artmaktad\u0131r.<\/p>\n\n\n\n

8-<\/mark><\/strong>\u00d6zellikle 5 y\u0131ldan daha uzun s\u00fcre do\u011fum kontrol hap\u0131 kullananlarda meme kanseri ortaya \u00e7\u0131kma ihtimali do\u011fum kontrol hap\u0131 kullan\u0131m\u0131n\u0131 b\u0131rakt\u0131ktan 5 y\u0131l sonra dahi y\u00fcksek olmaya devam etmektedir(4,9,10).<\/p>\n\n\n\n

9-<\/mark><\/strong>Do\u011fum kontrol hap\u0131 kullan\u0131m\u0131na ba\u015flama ya\u015f\u0131 da meme kanserinin ortaya \u00e7\u0131kma ihtimalini etkilemektedir. <\/p>\n\n\n\n

10-<\/mark><\/strong>Ergenlik d\u00f6neminde ba\u015flayan meme b\u00fcy\u00fcmesi (proliferation) genellikle 20 li ya\u015flar\u0131n ba\u015f\u0131nda tamamlanmaktad\u0131r.<\/p>\n\n\n\n

Memenin b\u00fcy\u00fcmesi devam ederken do\u011fum kontrol haplar\u0131 gibi kanseri tetikleyen maddelerin (carcinogens) kullan\u0131lmas\u0131 meme kanseri ihtimalini artt\u0131rmaktad\u0131r.<\/mark><\/strong><\/p>\n\n\n\n

Bu nedenle 18-20 ya\u015flar\u0131ndan \u00f6nce, ergenlik d\u00f6neminde, ba\u015flanarak uzun s\u00fcre do\u011fum kontrol hap\u0131 kullan\u0131lmas\u0131 meme kanseri g\u00f6r\u00fclme ihtimalini daha fazla artt\u0131rmaktad\u0131r (3,4,9,10). <\/mark><\/strong><\/p>\n\n\n\n

Meme kanseri ortaya \u00e7\u0131kma ihtimali en \u00e7ok do\u011fum kontrol hap\u0131 kullan\u0131m\u0131na 18 ya\u015f\u0131ndan \u00f6nce ba\u015flay\u0131p 10 y\u0131ldan daha uzun s\u00fcre kullananlarda artmaktad\u0131r(5).<\/mark><\/strong><\/p>\n\n\n\n

G\u00fcn\u00fcm\u00fczde en \u00e7ok kullan\u0131lan do\u011fum kontrol haplar\u0131 \u00f6strojen miktar\u0131na ve progesteron \u00e7e\u015fidine g\u00f6re a\u015fa\u011f\u0131da belirtilmi\u015ftir. <\/mark><\/strong><\/p>\n\n\n\n

Bu do\u011fum kontrol haplar\u0131n\u0131 ge\u00e7mi\u015fte kullanan ya da \u015fimdi kullanmakta olan kad\u0131nlarda meme kanseri ihtimalinde g\u00f6r\u00fclen art\u0131\u015f\u0131 a\u015fa\u011f\u0131da g\u00f6rebilirsiniz(4);<\/mark><\/strong><\/p>\n\n\n\n

50 \u00b5g ethinyl estradiol + levonorgestrel<\/strong> kullananlarda meme kanseri  1.21 kat artmaktad\u0131r.<\/p>\n\n\n\n

20 \u00b5g ethinyl estradiol + levonorgestrel<\/strong> kullananlarda meme kanseri 1.33 kat artmaktad\u0131r.<\/p>\n\n\n\n

20 \u00b5g ethinyl estradiol + gestodene<\/strong> kullananlarda meme kanseri 1.20 kat artmaktad\u0131r.<\/p>\n\n\n\n

35 \u00b5g ethinyl estradiol + cyproterone acetate (siproteron asetat)<\/strong> kullananlarda meme kanseri 1.44 kat artmaktad\u0131r.<\/p>\n\n\n\n

30 \u00b5g ethinyl estradiol + drospirenone<\/strong> kullananlarda meme kanseri 1.1 kat artmaktad\u0131r.<\/p>\n\n\n\n

35 \u00b5g ethinyl estradiol + norgestimate <\/strong>kullananlarda meme kanseri 1.22 kat artmaktad\u0131r.<\/p>\n\n\n\n

20 \u00b5g ethinyl estradiol + desogestre<\/strong>l kullananlarda meme kanseri 1.12 kat artmaktad\u0131r.<\/p>\n\n\n\n

Polikistik over sendromu tedavisinde do\u011fum kontrol hap\u0131 kullan\u0131lmas\u0131 do\u011fru de\u011fildir.<\/mark><\/strong><\/p>\n\n\n\n

 Fakat, tedavi etkinli\u011finin olmamas\u0131na ve de bir k\u0131sm\u0131 hayati tehlikeye sahip olan bir \u00e7ok yan etkiye sahip olmas\u0131na ra\u011fmen do\u011fum kontrol haplar\u0131 polikistik over sendromu tedavisinde halen yayg\u0131n olarak kullan\u0131lmaktad\u0131r.<\/mark><\/strong><\/p>\n\n\n\n

Halbuki, polikistik over sendromu\u2019nun \u00e7ok daha ba\u015far\u0131l\u0131 ve az yan etkisi olan tedavi y\u00f6ntemleri vard\u0131r. <\/strong><\/p>\n\n\n\n

 Kaynaklar<\/strong><\/p>\n\n\n\n

1-Polycystic ovarian syndrome (PCOS), related symptoms\/sequelae, and breast cancer risk in a population-based case-control study. Kim J, Mersereau JE, Khankari N, Bradshaw PT, McCullough LE, Cleveland R, Shantakumar S, Teitelbuam SL, Neugut AI, Senie RT,Gammon MD.Cancer Causes Control . 2016 Mar;27(3):403-14.<\/p>\n\n\n\n

2-The action of estrogens and progestogens in the young female breast. Zolfaroli I, Tar\u00edn JJ, Cano A. Eur J Obstet Gynecol Reprod Biol. 2018 Mar 28.<\/p>\n\n\n\n

3-The pill and the breast. Drife JO. IPPF Med Bull. 1984 Dec;18(6):1-2.<\/p>\n\n\n\n

4-Contemporary Hormonal Contraception and the Risk of Breast Cancer. M\u00f8rch LS, \u00f8Skovlund CW, Hannaford PC, Iversen L, Fielding S, Lidegaard \u00d8. N Engl J Med. 2017 Dec 7;377(23):2228-2239.<\/p>\n\n\n\n

5-Breast cancer among young U.S. women in relation to oral contraceptive use. White E, Malone KE, Weiss NS, Daling JR. J Natl Cancer Inst. 1994 Apr 6;86(7):505-14.<\/p>\n\n\n\n

6-Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies. Collaborative Group on Hormonal Factors in Breasst Cancer. Lancet 1996 Jun 22;347(9017): 1713-27.<\/p>\n\n\n\n

7-Impact of teenage oral contraceptive use in a population-based series of early-onset breast cancer cases who have undergone BRCA mutation testing. Jernstr\u00f6m H, Loman N, Johannsson OT, Borg A, Olsson H. Eur J Cancer. 2005 Oct;41(15):2312-20.<\/p>\n\n\n\n

8-Hormonal content and potency of oral contraceptives and breast cancer risk among young women. Althuis MD, Brogan DR, Coates RJ, Daling JR, Gammon MD, Malone KE, Schoenberg JB, Brinton LA. Br J Cancer. 2003 Jan 13;88(1):50-7.<\/p>\n\n\n\n

9-Oral contraceptives and breast cancer: review of the epidemiologic literature. Thomas DB. Contraception. 1991 Jun;43(6):597-642.<\/p>\n\n\n\n

10-Cellular basis of breast cancer susceptibility. Russo J, Russo IH. Oncol Res. 1999;11(4):169-78.<\/p>\n","protected":false},"excerpt":{"rendered":"

Meme kanseri kad\u0131nlarda en fazla kar\u015f\u0131la\u015f\u0131lan kanserdir. 1-Meme kanseri g\u00f6r\u00fclme ihtimalini (riskini) artt\u0131ran ve azaltan baz\u0131 \u00f6zellikler polikistik over sendromu olan kad\u0131nlar\u0131n bir k\u0131sm\u0131nda bulunmaktad\u0131r. 2-Meme kanseri \u00e7o\u011funlukla ileri ya\u015flarda menopoz sonras\u0131 d\u00f6nemde ortaya \u00e7\u0131kmaktad\u0131r. 3-Gen\u00e7 ya\u015flarda g\u00f6r\u00fclen meme kanseri \u00e7o\u011funlukla do\u011fum kontrol hap\u0131 kullan\u0131m\u0131 ile birlikte genetik (ailesel) nedenlere ba\u011fl\u0131d\u0131r(1). 4–\u0130leri ya\u015flarda, menopoz sonras\u0131 d\u00f6nemde,\u00a0ortaya \u00e7\u0131kan meme kanseri polikistik […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8353","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8353","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/comments?post=8353"}],"version-history":[{"count":14,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8353\/revisions"}],"predecessor-version":[{"id":11580,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8353\/revisions\/11580"}],"wp:attachment":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/media?parent=8353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}