{"id":8427,"date":"2025-09-28T10:59:03","date_gmt":"2025-09-28T10:59:03","guid":{"rendered":"https:\/\/polikistikover.net\/yeni\/?page_id=8427"},"modified":"2025-11-22T02:18:10","modified_gmt":"2025-11-22T02:18:10","slug":"meme-kanseri-ve-polikistik-over-sendromu","status":"publish","type":"page","link":"https:\/\/polikistikover.net\/yeni\/meme-kanseri-ve-polikistik-over-sendromu\/","title":{"rendered":"Meme Kanseri ve Polikistik Over Sendromu"},"content":{"rendered":"\n

1-<\/mark><\/strong>Meme kanseri kad\u0131nlarda en fazla kar\u015f\u0131la\u015f\u0131lan kanserdir.<\/p>\n\n\n\n

2-<\/mark><\/strong>Meme kanseri g\u00f6r\u00fclme ihtimalini (riskini) artt\u0131ran ve azaltan baz\u0131 \u00f6zellikler polikistik over sendromu olan kad\u0131nlar\u0131n bir k\u0131sm\u0131nda bulunmaktad\u0131r.<\/p>\n\n\n\n

3-<\/mark><\/strong>Meme kanseri \u00e7o\u011funlukla ileri ya\u015flarda menopoz sonras\u0131 d\u00f6nemde ortaya \u00e7\u0131kmaktad\u0131r.<\/p>\n\n\n\n

4-<\/mark><\/strong>Gen\u00e7 ya\u015flarda g\u00f6r\u00fclen meme kanseri \u00e7o\u011funlukla do\u011fum kontrol hap\u0131 kullan\u0131m\u0131 ile birlikte genetik (ailesel) nedenlere ba\u011fl\u0131d\u0131r(9).<\/p>\n\n\n\n

5-<\/strong><\/mark> \u0130leri ya\u015flarda, menopoz sonras\u0131 d\u00f6nemde, ortaya \u00e7\u0131kan meme kanseri polikistik over sendromu ile daha \u00e7ok ili\u015fkilidir.<\/p>\n\n\n\n

6-<\/mark><\/strong>Polikistik over sendromu olan kad\u0131nlar\u0131n bir k\u0131sm\u0131nda meme kanseri ortaya \u00e7\u0131kma ihtimalini artt\u0131ran \u00f6zellikler di\u011fer bir k\u0131sm\u0131nda ise meme kanseri g\u00f6r\u00fclme ihtimalini azaltan \u00f6zellikler bulunmaktad\u0131r.<\/p>\n\n\n\n

Polikistik over sendromu\u2019nda meme kanseri g\u00f6r\u00fclme ihtimalini artt\u0131ran \u00f6zellikler;<\/mark><\/strong><\/p>\n\n\n\n

1-<\/mark><\/strong> <\/mark>\u015ei\u015fmanl\u0131k ve kar\u0131n (bel) b\u00f6lgesindeki ya\u011flanma art\u0131\u015f\u0131 meme kanseri g\u00f6r\u00fclme ihtimalini artt\u0131rmaktad\u0131r(1,2,3).<\/p>\n\n\n\n

Polikistik over sendromu olan kad\u0131nlar\u0131n bir k\u0131sm\u0131nda meme kanseri g\u00f6r\u00fclme ihtimalini artt\u0131ran \u00f6zelliklerden olan \u015fi\u015fmanl\u0131k ve kar\u0131n (Bel) b\u00f6lgesindeki ya\u011flanma art\u0131\u015f\u0131n\u0131n kal\u00e7a b\u00f6lgesinden daha fazla olmas\u0131 durumu vard\u0131r.<\/p>\n\n\n\n

2-<\/mark><\/strong> \u0130ns\u00fclin direnci ve onu takiben geli\u015fen \u015feker hastal\u0131\u011f\u0131 meme kanseri g\u00f6r\u00fclme ihtimalini artt\u0131rmaktad\u0131r(4,5,6,7).<\/p>\n\n\n\n

\u0130ns\u00fclin direnci ve ins\u00fclin direncine kar\u015f\u0131 fazla miktarda \u00fcretilen ins\u00fclin hormonu (hiperins\u00fclinemi) \u015fi\u015fmanl\u0131ktan ba\u011f\u0131ms\u0131z olarak yani ins\u00fclin direnci olan zay\u0131f kad\u0131nlarda da meme kanseri ihtimalini artt\u0131rmaktad\u0131r(4,7). <\/p>\n\n\n\n

Meme kanseri olu\u015fan b\u00f6lgede fazla say\u0131da ins\u00fclin hormonuna ba\u011flanan al\u0131c\u0131lar (resept\u00f6rler) bulunmaktad\u0131r(5). Bu al\u0131c\u0131lara tutunan fazla miktarda \u00fcretilen ins\u00fclin hormonu meme kanserinin b\u00fcy\u00fcmesine neden olmaktad\u0131r.<\/p>\n\n\n\n

Ayr\u0131ca ins\u00fclin direncine ba\u011fl\u0131 olarak fazla miktarda \u00fcretilen ins\u00fclin hormonu sex hormon binding globulin miktar\u0131n\u0131 azaltarak kanda serbest dola\u015fan \u00f6strojen miktar\u0131n\u0131 artt\u0131rmaktad\u0131r. Serbest dola\u015fan \u00f6strojen miktar\u0131n\u0131n fazla olmas\u0131 meme kanseri ihtimalini artt\u0131ran ba\u015fka bir durumdur.<\/p>\n\n\n\n

Polikistik over sendromu olan kad\u0131nlar\u0131n yakla\u015f\u0131k yar\u0131s\u0131nda ins\u00fclin direnci vard\u0131r. Protein miktar\u0131 d\u00fc\u015f\u00fck buna kar\u015f\u0131l\u0131k karbonhidrat miktar\u0131 fazla olan yani glisemik indeksi y\u00fcksek beslenme bi\u00e7imi ve hareketsiz bir ya\u015fam s\u00fcr\u00fclmesi polikistik over sendromu olan kad\u0131nlarda meme kanseri ihtimalini artt\u0131ran durumlardan biri olan ins\u00fclin direncinin ortaya \u00e7\u0131kmas\u0131n\u0131 kolayla\u015ft\u0131rmaktad\u0131r(8).<\/p>\n\n\n\n

3-<\/mark><\/strong> Do\u011fum kontrol hap\u0131 kullan\u0131m\u0131 meme kanseri ihtimalini art\u0131rmaktad\u0131r(10).<\/p>\n\n\n\n

Do\u011fum kontrol haplar\u0131n\u0131n i\u00e7inde bulunan \u00f6strojen (estradiol) ve progesteron hormonlar\u0131 meme kanseri ile ili\u015fkilidir. \u0130lk do\u011fumdan \u00f6nce, 25 ya\u015f\u0131ndan \u00f6nce ve son do\u011fumdan \u00f6nce uzun s\u00fcre do\u011fum kontrol hap\u0131 kullan\u0131lmas\u0131 meme kanseri ihtimalini artt\u0131rmaktad\u0131r(11).<\/p>\n\n\n\n

 Polikistik over sendromu tedavisinde do\u011fum kontrol hap\u0131 kullan\u0131lmas\u0131 do\u011fru de\u011fildir. Polikistik over sendromu\u2019nda do\u011fum kontrol hap\u0131 kullanan gen\u00e7 kad\u0131nlarda meme kanseri daha fazla g\u00f6r\u00fclmektedir(9). <\/p>\n\n\n\n

Do\u011fum kontrol haplar\u0131 polikistik over sendromu\u2019nu tedavi etmemektedir. Fakat, meme kanseri ihtimalini artt\u0131rmas\u0131na ra\u011fmen polikistik over sendromu\u2019nda halen yayg\u0131n olarak kullan\u0131lmaktad\u0131r.<\/p>\n\n\n\n

4-<\/mark><\/strong> Sex Hormon Binding Globulin (SHBG) \u00f6strojen hormonunu ba\u011flayarak meme dokusunda etki etmesini \u00f6nlemektedir.<\/p>\n\n\n\n

Bu nedenle SHBG nin do\u011fu\u015ftan az miktarda \u00fcretilmesi ya da yap\u0131sal bozuklu\u011funun olmas\u0131 serbest \u00f6strojen miktar\u0131n\u0131 artt\u0131rarak meme kanseri ihtimalini artt\u0131rmaktad\u0131r. <\/p>\n\n\n\n

\u0130ns\u00fclin direnci ve v\u00fccut ya\u011f oran\u0131n\u0131n fazla oldu\u011fu \u015fi\u015fmanl\u0131k SHBG in az miktarda \u00fcretilmesine neden olmaktad\u0131r. <\/p>\n\n\n\n

Polikistik over sendromu olan kad\u0131nlar\u0131n \u00f6nemli bir k\u0131sm\u0131nda ins\u00fclin direnci ve v\u00fccut ya\u011f oran\u0131n\u0131n fazla oldu\u011fu \u015fi\u015fmanl\u0131k vard\u0131r. <\/p>\n\n\n\n

Polikistik over sendromu olan kad\u0131nlar\u0131n bir k\u0131sm\u0131nda da ins\u00fclin direnci ve\/veya \u015fi\u015fmanl\u0131k olmasa da SHBG miktar\u0131 do\u011fu\u015ftan (genetik) \u00e7ok d\u00fc\u015f\u00fck bulunmaktad\u0131r. Bu her iki durum da polikistik over sendromu olan kad\u0131nlarda meme kanseri ihtimalini artt\u0131rmaktad\u0131r(12,13,14).<\/p>\n\n\n\n

5-<\/mark><\/strong> \u0130lk adet kanamas\u0131n\u0131n (Menar\u015f) erken ya\u015fta ba\u015flamas\u0131 veya ge\u00e7 ya\u015fta menopoza girilmesi meme kanseri ihtimalini artt\u0131rmaktad\u0131r.<\/p>\n\n\n\n

Do\u011fum kontrol haplar\u0131 ile d\u0131\u015far\u0131dan al\u0131nan \u00f6strojen ve progesteron hormonlar\u0131 adet d\u00f6ng\u00fcs\u00fcnde zaten yumurtal\u0131klarda \u00fcretilmektedir. Bu nedenle erken ya\u015fta adet d\u00f6ng\u00fcs\u00fc ba\u015flayan (menar\u015f) ve ge\u00e7 ya\u015fta adet d\u00f6ng\u00fcs\u00fc biten (menopoz) kad\u0131nlarda \u00f6strojen ve progesteron hormonlar\u0131na daha fazla maruz kal\u0131nmas\u0131 meme kanseri ihtimali artt\u0131rmaktad\u0131r(15).<\/p>\n\n\n\n

Polikistik over sendromu\u2019nda meme kanseri g\u00f6r\u00fclme ihtimalini azaltan \u00f6zellikler;<\/mark><\/strong><\/p>\n\n\n\n

1-<\/mark><\/strong> Yumurtay\u0131 i\u00e7inde ta\u015f\u0131yan keseci\u011fin (folik\u00fcl) geli\u015fiminin yava\u015f olmas\u0131 (oligoovulasyon) ya da olmamas\u0131 (anovulasyon) meme kanseri ihtimalini azaltmaktad\u0131r.<\/p>\n\n\n\n

2-<\/mark><\/strong> Bir adet d\u00f6ng\u00fcs\u00fcnde yumurtlamadan \u00f6nce (folik\u00fcler d\u00f6nem) \u00f6strojen hormonu miktar\u0131 h\u0131zla artar ve yumurtlamadan sonra adet kanamas\u0131 ba\u015flayana kadar fazla miktarda kalmaya devam eder, fakat, progesteron hormonu yumurtlamadan \u00f6nce az miktarda \u00fcretilmektedir ve yumurtlamadan sonra adet kanamas\u0131 ba\u015flayana kadar (luteal d\u00f6nem) fazla miktardad\u0131r.<\/p>\n\n\n\n

3-<\/mark><\/strong> Yumurtlaman\u0131n olmamas\u0131 sonucu progesteron hormonu \u00fcretilmemektedir.<\/p>\n\n\n\n

4-<\/mark><\/strong> \u00d6strojen ve progesteron hormonlar\u0131 birlikte meme kanseri ihtimalini artt\u0131rmaktad\u0131r.<\/p>\n\n\n\n

5-<\/mark><\/strong> Yumurtlama olmad\u0131\u011f\u0131 i\u00e7in \u00f6strojen hormonun az miktarda ve progesteron hormonunun da \u00fcretilmemesi meme kanseri ihtimalini azaltmaktad\u0131r(16,17).<\/p>\n\n\n\n

6-<\/mark><\/strong> Polikistik over sendromu olan kad\u0131nlar\u0131n bir k\u0131sm\u0131nda yumurta geli\u015fimi ve yumurtlama sorunu oldu\u011fu i\u00e7in meme kanseri ihtimali azalmaktad\u0131r(18).<\/p>\n\n\n\n

Kaynaklar<\/strong><\/p>\n\n\n\n

1-Body fat distribution and breast cancer in the Framingham Study. Ballard-Barbash R, Schatzkin A, Carter CL, Kannel WB, Kreger BE, D\u2019Agostino RB, Splansky GL, Anderson KM, Helsel WE J Natl Cancer Inst. 1990 Feb 21;82(4):286-90.<\/p>\n\n\n\n

2-Body fat distribution and obesity in pre- and postmenopausal breast cancer. Sonnenschein E, Toniolo P, Terry MB, Bruning PF, Kato I, Koenig KL, Shore RE. Int J Epidemiol. 1999 Dec;28(6):1026-31.<\/p>\n\n\n\n

3-Increased incidence of carcinoma of the breast associated with abdominal adiposity in postmenopausal women. Folsom AR, Kaye SA, Prineas RJ, Potter JD, Gapstur SM, Wallace RB. Am J Epidemiol. 1990 May;131(5):794-803.<\/p>\n\n\n\n

4-Insulin resistance and breast-cancer risk.Bruning PF, Bonfr\u00e8r JM, van Noord PA, Hart AA, de Jong-Bakker M, Nooijen WJ. Int J Cancer. 1992 Oct 21;52(4):511-6.<\/p>\n\n\n\n

5-Elevated insulin receptor content in human breast cancer. Papa V, Pezzino V, Costantino A, Belfiore A, Giuffrida D, Frittitta L, Vannelli GB, Brand R, Goldfine ID, Vigneri R. J Clin Invest. 1990 Nov;86(5):1503-10.<\/p>\n\n\n\n

6-Association between insulin resistance and breast carcinoma: a systematic review and meta-analysis. Hernandez AV, Guarnizo M, Miranda Y, Pasupuleti V, Deshpande A, Paico S, Lenti H, Ganoza S, Montalvo L, Thota P,Lazaro H. PLoS One. 2014 Jun 9;9(6):e99317.<\/p>\n\n\n\n

7-Selected medical conditions and risk of breast cancer. Talamini R, Franceschi S, Favero A, Negri E, Parazzini F, La Vecchia C. Br J Cancer. 1997;75(11):1699-703.<\/p>\n\n\n\n

8-Intake of macronutrients and risk of breast cancer. Franceschi S, Favero A, Decarli A, Negri E, La Vecchia C, Ferraroni M, Russo A, Salvini S, Amadori D, Conti E, Montella M, Giacosa A. Lancet. 1996 May 18;347(9012):1351-6.<\/p>\n\n\n\n

9-Polycystic ovarian syndrome (PCOS), related symptoms\/sequelae, and breast cancer risk in a population-based case-control study. Kim J, Mersereau JE, Khankari N, Bradshaw PT, McCullough LE, Cleveland R, Shantakumar S, Teitelbuam SL, Neugut AI1, Senie RT,Gammon MD.Cancer Causes Control . 2016 Mar;27(3):403-14.<\/p>\n\n\n\n

10-The action of estrogens and progestogens in the young female breast. Zolfaroli I, Tar\u00edn JJ, Cano A. Eur J Obstet Gynecol Reprod Biol. 2018 Mar 28.<\/p>\n\n\n\n

11-The pill and the breast. Drife JO. IPPF Med Bull. 1984 Dec;18(6):1-2.<\/p>\n\n\n\n

12-Association of anthropometric, androgenic and insulin-related features with polymorphisms in exon 8 of SHBG gene in women with polycystic ovary syndrome. Hac\u0131hanefio\u011flu B, Aybey B, Hakan \u00d6z\u00f6n Y, Berkil H, Kar\u015f\u0131da\u011f K. Gynecol Endocrinol. 2013 Apr;29(4):361-4.<\/p>\n\n\n\n

13-Polymorphisms in the SHBG gene influence serum SHBG levels in women with polycystic ovary syndrome. Wickham EP 3rd, Ewens KG, Legro RS, Dunaif A, Nestler JE, Strauss JF 3rd. J Clin Endocrinol Metab. 2011 Apr;96(4):E719-27.<\/p>\n\n\n\n

14-The (TAAAA)n microsatellite polymorphism in the SHBG gene influences serum SHBGlevels in women with polycystic ovary syndrome. Ferk P, Teran N, Gersak K. NHum Reprod. 2007 Apr;22(4):1031-6.<\/p>\n\n\n\n

15-Endogenous hormones and breast cancer risk. Bernstein L, Ross RK Epidemiol Rev. 1993;15(1):48-65.<\/p>\n\n\n\n

16-Do regular ovulatory cycles increase breast cancer risk? Henderson BE, Ross RK, Judd HL, Krailo MD, Pike MC. Cancer.<\/a> 1985 Sep 1;56(5):1206-8.<\/p>\n\n\n\n

17-The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. Colditz GA, Hankinson SE, Hunter DJ, Willett WC, Manson JE. N Engl J Med. <\/a>1995 Jun 15;332(24):1589-93.<\/p>\n\n\n\n

18-A prospective study of infertility due to ovulatory disorders, ovulation induction, and incidence of breast cancer. Terry KL, Willett WC, Rich-Edwards JW, Michels KB. Arch Intern Med. 2006 Dec 11-25;166(22):2484-9.<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

1-Meme kanseri kad\u0131nlarda en fazla kar\u015f\u0131la\u015f\u0131lan kanserdir. 2-Meme kanseri g\u00f6r\u00fclme ihtimalini (riskini) artt\u0131ran ve azaltan baz\u0131 \u00f6zellikler polikistik over sendromu olan kad\u0131nlar\u0131n bir k\u0131sm\u0131nda bulunmaktad\u0131r. 3-Meme kanseri \u00e7o\u011funlukla ileri ya\u015flarda menopoz sonras\u0131 d\u00f6nemde ortaya \u00e7\u0131kmaktad\u0131r. 4-Gen\u00e7 ya\u015flarda g\u00f6r\u00fclen meme kanseri \u00e7o\u011funlukla do\u011fum kontrol hap\u0131 kullan\u0131m\u0131 ile birlikte genetik (ailesel) nedenlere ba\u011fl\u0131d\u0131r(9). 5- \u0130leri ya\u015flarda, menopoz sonras\u0131 d\u00f6nemde, ortaya \u00e7\u0131kan meme kanseri […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8427","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8427","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/comments?post=8427"}],"version-history":[{"count":20,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8427\/revisions"}],"predecessor-version":[{"id":12925,"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/pages\/8427\/revisions\/12925"}],"wp:attachment":[{"href":"https:\/\/polikistikover.net\/yeni\/wp-json\/wp\/v2\/media?parent=8427"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}